Results of Conventional Radiotherapy in Hypopharyngeal Cancer

Nam,  Taek Keun; Park,  Seung Jin; Ahn,  Sung Ja; Chung,  Woong Ki; Nah,  Byung Sik

J Korean Soc Ther Radiol > Volume 13(2); 1995 > Article

Original Article

Journal of the Korean Society for Therapeutic Radiology 1995;13(2): 143-148.

Results of Conventional Radiotherapy in Hypopharyngeal Cancer

Taek Keun Nam, Seung Jin Park, Sung Ja Ahn, Woong Ki Chung, Byung Sik Nah

¹Department of Therapeutic Radiology, Chonnam University Medical School, Kwangju, Korea.
²Department of Radiology, Gyeongsang University Hospital, Jinju, Korea.

ABSTRACT

PURPOSE:
We tried to evaluate the role of conventional radiotherapy alone or with neoadjuvant chemotherapy in the hypopharyngeal cncer by retrospective analysis.
MATERIALS AND METHODS:
Between Jul. 1985 and Sep. 1992, 42 patinets of hypopharyngeal cancer were treated by conventional radiotherapy alone or combined with neoadjuvant chemotherapy. The male to female ration was 20:1 with a median age of 58 years. Twelve patients were treated by conventional radiotherapy alone and 30 patients were treated by neoadjuvant chemotherapy and radiotherapy.
RESULTS:
Seven patients were stage I, II and the patients with stage III and IV were 10 and 25, respectively at the time of presentation. The overall survival and disease-specific survival rates at 24 month were 12.9% and 15.5%, respectively. Two-year survival rates of stage I+II and III+IV patients were 50% and 6.3%, respectively(p<0.05). Sixteen patients (38%) revealed CR and 26 patients(62%) revealed less that CR at the end of radiotherapy and their 2-year survival rates were 31.3% and 0%, respectively(p<0.05). On univariate anaysis, stage, T-stage, N-stage and treatment response were the significant prognositc factors, but only stage an dtreatment response were significant on multivariate analysis.
CONCLUSION:
This conventional radiotherapy alone or with neoadjuvant chemotherapy does not seem to be sufficient in the treatment of most advanced hypopharyngeal cancer. Therefore other treatment modalities such as hyperfractionation or concurrent chemoradiotherapy should be considered.

Key Words: Hypopharyngeal cancer, Radiotherapy, Chemotherapy