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- Case Report
- The Role of Radiation Therapy in the Treatment of Intracranial Glioma: Retrospective Analysis of 96 Cases
- Yeon Sil Kim, Ki Mun Kang, Byung Ock Choi, Sei Chul Yoon, Kyung Sub Shin, Jun Gi Kang
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Radiat Oncol J. 1993;11(2):249-258.
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Between March 1983 and December 1989, ninety-six patients with intracranial glioma were treated in the Department of Therapeutic Radiology, Kangnam St. Mary's Hospital, Catholic University Medical College. We retrospectively reviewed each case to evaluate variable factors influencing the treatment results and to develop an optimal therapy Policy. Median follow-up is 57 months(range:31~133 months). Of the 96 patients, 60(63%) were males... |
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- Clinical Trial
- Sequential Chemotherapy and Radiation Therapy for Advanced Nasopharyngeal Carcinoma
- In Kyu Park, Sang Bo Kim, Sang Mo Yun, Jae Cheol Kim, Jun Sik Park
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Radiat Oncol J. 1993;11(2):259-266.
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Between January 1985 and July 1592, 52 patients with locally advanced nasopharyngeal carcinoma were studied retrospectively for the effectiveness of sequential chemotherapy and radiation therapy. The male to female ratio was 3.3:1 with a median age of 41 years. Forty patients had squamous cell carcinoma and the remaining 12 had undifferentiated carcinoma. Seven patients had stage III disease and the... |
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- Randomized Controlled Trial
- Hyperfractionated Radiotherapy Following Induction Chemotherapy for Stage III Non-Small Cell Lung Cancer: Random iced for Adjuvant Chemotherapy vs. Observation
- Eun Kyung Choi, Hye Sook Chang, Seung Do Ahn, Kwang Mo Yang, Cheol Won Suh, Kyoo Hyung Lee, Jung Shin Lee, Sang Hee Kim, Youn Suk Ko, Woo Sung Kim, Won Dong Kim, Koun Sik Song, Kwang Hyun Sohn
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Radiat Oncol J. 1993;11(2):295-302.
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Since Jan. 1991 a prospective randomized study for Stage III unresectable non small cell lung cancer(NSCLC) has been conducted to evaluate the response rate and tolerance of induction chemotherapy with MVP followed by hyperfractionated radiotherapy and evaluate the efficacy of maintenance chemotherapy in Asan Medical Center. All patients in this study were treated with hypefractionated radiotherapy (120 cGy/fx BID, 0480... |
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- Original Articles
- Radiation Induced G2 Chromatic Break and Repairs Kinetics in Human Lymphoblastoid Cells
- Jinsil Seong
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Radiat Oncol J. 1993;11(2):193-204.
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In understanding radiosensitivity a new concept of inherent radiosensitivity based on individuality and heterogeneity within a population has recently beer explored. There has been some discussion of possible mechanism underlying differences in radiosensitivity between cells. Ataxia telangiectasia(AT), a rare autosomal recessive genetic disorder, is characterized by hypersensitivity to lonizing radiation and other DNA damaging agents at the cellular level. There... |
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- Effect of g-ray Irradiation On the Activities of Monoamine Oxidase in Rat Brain and Liver
- Joo Young Kim, Myung Sun Choi, Myung Un Choi
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Radiat Oncol J. 1993;11(2):205-218.
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In order to evalute the effects of radiation on mammalian neuronal system, we have examined the effect of gamma-ray radiation on the monoamine oxidase(MAO) activity in monoaminergic neurons. Following the whole body irradiation, MAO activity in the rat brain was measured as well as in the liver for the comparative studies between the neuronal and nonneuronal system. The effects of... |
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- Evaluation of DNA Double Strand Breaks in Human and Mouse Lymphocyte Following gamma-Irradiation
- Tae Hwan Kim, Sung Ho Kim, In Yong Chung, Chul Koo Cho, Kyung Hwan Koh, Seong Yul Yoo
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Radiat Oncol J. 1993;11(2):219-226.
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The evaluation of radiation-induced DNA double strand breaks(DSB) was made following irradiation of human lymphocytes, murille lymphocytes and EL-4 leukemia cells over a wide dose range of 60Co g-rays. In lipopolysacchande(LPS) or phytohemagglutinin(PHA)-stimulated murine lymphocytes, the slopes of the strand scission factor(SSF) revealed that lymphocytes with LPS increased DNA DSB formation by a factor of 1.432 (p<0.005). Furthermore, strand break... |
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- Effect of Radiotherapy on the Ascorbate (vitamin C) Levels in Whore Blood and Plasmas
- Gyu Young Choi, Sang Yoon
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Radiat Oncol J. 1993;11(2):227-232.
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The role of ascorbate as an antioxidant in the prevention and cure of disease that result from free radicals has been of considerable interest and controversy lately. As an antioxidant, we can expect it to protect against radiation damage caused by free radicals that are produced when radiation, especially sparsely ionizing radiation, interacts with living tissues. The plasma and whole... |
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- Analysis of Chromosomal Aberration Induced by Low Dose of Radiation
- Chun Ja Yi, Sung Whan Ha
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Radiat Oncol J. 1993;11(2):233-240.
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Chromosomal aberration analysis, as a basis for biological radiation dosimetry, was performed for radiation dose ranges below 150 cGy. The yield, ratio of lymphocytes with dicentric and/or ring chromosomes, was 0, 0, 0.4, 0.5, 0.6, 0.8, 1.8, 5.5, 8.0, and 18.5% for 0, 5, 10, 15, 20, 25, 50, 75, 100 and 150 cGy, respectively. The Qdr, ratio of dicentric... |
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- Clinical Report of 46 Intracranial Tumors with LINAC Based Stereotactic Radiosurgery
- Sei C Yoon, Tae S Suh, Sung W Kim, Ki M Kang, Yun S Kim, Byung O Choi, Hong S Jang, Kyo H Choi, Moon C Kim, Kyung S Shinn
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Radiat Oncol J. 1993;11(2):241-248.
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Between July 1988 and December 1992, we treated 45 patients who had deep seated inoperable or residual and/or recurrent intracranial tumors using LINAC based stereotactic radiosurgery at the Department of Therapeutic Radiology, Kangnam St. Mary's Hospital, Catholic University Medical College. Treated intracranial tumors included pituitary tumors(n=15), acoustic neurinomas(n=8), meningiomas(n=7), gliomas(n=6), craniopharyngiomas(n=4), pinealomas(n=3), hemangioblastomas(n=2), and solitary metastatic tumor from lung cancer... |
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- Radiotherapy for Oral Cavity Cancer
- Jae Won Shim, Seong Yul Yoo, Kyoung Hwan Koh, Chul Koo Cho, Hyong Geun Yun, Jae Young Kim
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Radiat Oncol J. 1993;11(2):267-276.
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Eighty five patients of oral cavity cancer, treated with radiation at the Department of Therapeutic Radiology, Korea Cancer Center Hospital, during the period from March 1985 to September 1990 were analyzed retrospectively. Among 85 patients, 37 patients were treated with radiation only and 48 patients were treated with radiation following surgery And 70 patients received external irradiation only by 60Co... |
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- Induction Chemotherapy Plus Radiation Compared with Surgery Plus Radiation in Patients with Advanced Laryngeal and Hypopharyngeal Cancer
- Ki Chang Keum, Chang Geol Lee, Gwi Eon Kim, Kyung Hee Lee
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Radiat Oncol J. 1993;11(2):277-284.
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BACKGROUND: We performed a retrospective study in patients with previously untreated advanced(Stage III or IV) laryngeal and hypopharyngeal cancer to compare the results of induction chemotherapy followed by definitive radiation therapy (CT+RT) with those of conventional laryngectomy and postoperative radiation therapy (OP+RT).
METHOD: Between 1985 and 1990, twenty four patients were treated with two or three courses of chemotherapy and radiation... |
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- Postoperative Radiation Therapy in Resected N2 Stage Non-Small Cell Lung Cancer
- Chang Geol Lee
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Radiat Oncol J. 1993;11(2):285-294.
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A total of forty patients with resected N2 stage non-small cell lung cancer treated with postoperative adjuvant radiation therapy between Jan. 1975 and Dec. 1990 at the Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center were retrospectively analysed to evaluate whether postoperative radiation therapy improves survival. Patterns of failure and prognostic factors affecting survival were also... |
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- Therapeutic Results of Radiation Therapy Alone and Combination with Chemotherapy in Non-Small Cell Lung Carcinoma
- Ju Ree Kim, Hyun Suk Suh
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Radiat Oncol J. 1993;11(2):303-310.
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Between November 1983 and December 1992, 121 patients with non-small cell lung cancer were treated with radiotherapy alone or combined with chemotherapy in Inje University, Seoul Paik Hospital. Of these, 97 patients were evaluable and analyzed retrospectively. Group 1(n=62) was treated with radiotherapy alone and group 2(n=35) combined with chemotherapy. There were 7 patients, 1 patient with stage I and... |
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- Local Control and Survival in Radiation Treatment of Locally Advanced Non-Small Cell Lung Cancer
- Mi Hee Song, Jin Yeung Yang, Won Young Oh, Nam Soo Yoo, In Soon Whang
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Radiat Oncol J. 1993;11(2):311-320.
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The retrospective analysis was performed on 37 patients with stage III non small cell lung cancer who received the radiotherapy from Feb. 1986 to Dec. 1990 at the Dept. of Radiation Oncology, National Medical Center. This analysis, with 29 patients (78.4%) having been followed from 10 to 60 months, was done to know the survival rate and significant prognostic factor.... |
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- Radiation-induced Pulmonary Damage in Lung Cancer Patients
- Su Mi Chung, Ihl Bohng Choi, Ki Mun Kang, In Ah Kim, Kyung Sub Shinn
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Radiat Oncol J. 1993;11(2):321-330.
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PURPOSE: A retrospective analysis was performed to evaluate the incidence of radiation induced lung damage after the radiation therapy for the patients with carcinoma of the lung.
MATHOD AND MATERIALS: Sixty-six patients with lung cancer (squamous cell carcinoma 27, adenocarcinDma 14, large cell carcinoma 2, small cell carcinoma 13, unknown 10) were treated with definitive, postoperative or palliative radiation therapy with... |
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- Treatment of Locally Advanced Pancreatic Cancer
- Dae Yong Kim, Sung Whan Ha
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Radiat Oncol J. 1993;11(2):331-336.
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From January 1981 to December 1991, forty patients with localized advanced carcinoma of the pancreas were treated at the Department of Therapeutic Radiology, Seoul National University Hospital. The treatment protocol consisted of two split course external radiation therapy with each 2000 cGy over two weeks separated by two week rest period.
Intravenous 5-fluorouracil (5-FU) was administered on the first three days... |
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- Postoperative Radiotherapy for the Early Stage Carcinoma of the Uterine cervix
- Jin Hee Kim, Ok Bae Kim, Tae Sung Lee
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Radiat Oncol J. 1993;11(2):337-346.
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This is a retrospective cohort analysis of 58 patients who treated with postoperative radiation therapy following radical hysterectomy and bilateral pelvic adenectomy for early stage carcinoma of uterine cervix between January 1988 and December 1990 at department of radiation oncology, Keimyoung University Hospital. Sixteen percent of patients(9/58) had chemotherapy. Most patients were FIGO I b (47 patients), and FIGO I... |
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- Therapeutic Results of Postoperative Radiation Therapy for Early Stage Uterine cervical Cancer
- Seung Hee Kang, Hyun Suk Suh
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Radiat Oncol J. 1993;11(2):347-354.
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This is a retrospective analysis of 67 patients with histologically proven invasive carcinoma of uterine cervix treated with surgery followed by adjuvant radiotherapy at Inje University Seoul Paik Hospital between october 1983 and september 1991. Postoperative radiotherapy was carried out in patients with high risks of locoregional recurrence such as positive pelvic lymph node (38 pts), large tumor size more... |
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- Preliminary Results of Concurrent Radiation Therapy and Chemotherapy in Locally Advanced Cervical Carcinoma
- K M Yang, S D Ahn, E K Choi, H S Chang, Y T Kim, J H Nam, J E Mok
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Radiat Oncol J. 1993;11(2):355-362.
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Since May 1991, authors have conducted a pilot study to determine the feasibility and evaluate the effect of concurrent radiation therapy and chemotherapy with 5-FU and Cis-platinum for locally advanced cervical cancer (stage IIB-IVA). Radiation therapy consisted of external irradiation to whole pelvis (4140 cGy/23 fx) in 4.5 weeks followed by high dose rate intracavitary radiation therapy (HDR ICRT) to... |
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- Carcinoma of the Uterine Cervix Treated with External Beam Irradiation Alone
- Mi Sook Kim, Sung Whan Ha
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Radiat Oncol J. 1993;11(2):363-368.
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A retrospective analysis was performed on 42 patients with carcinoma of the uterine cervix who were treated with external beam(EB) radiation therapy alone at the Department of Therapeutic Radiology, Seoul National University Hospital from March 1979 to December 1988. After whole pelvic field irradiation of 50 Gy, all the patients received additional booster dose of 12-22Gy to the primary tumor.... |
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- Cancinoma of Uterine Cervix Treated with High Dose Rate Intracavitary Irradiation: 1. Patterns of Failure
- Ok Bae Kim, Tae Jin Choi, Jin Hee Kim, Ho Jun Lee, Yung Ae Kim, Young Wook Suh, Tae Sung Lee, Soon Do Cha
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Radiat Oncol J. 1993;11(2):369-376.
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226 patients with carcinoma of the uterine cervix treated with curative radiation therapy at the Department of Therapeutic Radiology, Dongsan hospital, Keimyung university, School of medicine, from July, 1988 to May, 1991 were evaluated. The patients with all stages of the disease were included in this study. The maximum and mean follow up durations were 60 and 43 months. The... |
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- The Relationship between Radiation Dose and Late Complication of Bladder in Carcinoma of the Uterine Cervix
- Sung Whan Ha, Woong Ki Chung, Jong Hoon Kim
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Radiat Oncol J. 1993;11(2):377-386.
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Five hundred and fifty patients treated for carcinoma of the uterine cervix at the Department of Therapeutic Radiology, Seoul National University Hospital from 1979 to 1986, were analyzed retrospectively for late bladder complications. of them, 468 patients received primary radiotherapy for the cervix cancer in intact uterus, and the other 52 patients were treated postoperatively. The cumulative incidence of radiation... |
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- Pretreatment Prognostic Factors in Carcinoma of the Uterine Cervix
- Sung Whan Ha, Do Hoon Oh, Mi Sook Kim, Kyung Hwan Shin, Jae Sung Kim, Moo Song Lee, Keun Young Yoo
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Radiat Oncol J. 1993;11(2):387-396.
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To identify pretreatment prognostic factors in carcinoma of the uterine cervix, a retrospective analysis was undertaken of 510 patients treated with curative radiation therapy in Seoul National University Hospital during the 7 year period, from March 1979 through December 1986. According to FIGO classification, 35 patients were stage IB, 89 were stage IIA, 232 were stage IIB, 8 were stage... |
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- Value of Squamous Cell Carcinoma Associated Antigen (TA-4) in Patients with Invasive Carcinoma of the Uterine Cervix
- Moon June Cho, Jae Sung Kim, Seoung Ho Park, Sang Lyun Nam
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Radiat Oncol J. 1993;11(2):397-402.
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We investigated the usefulness of tumor-associated antigen (TA-4) by a radioimmunoasay method in estimating the extent of disease and tracking the clinical course of disease in 58 patients with cervical cancer. According to our results and those of other authors, the normal range of serum TA-4 was arbitrarily taken to be less than 2 ng/ml. The proportion of the pretreatment... |
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- The Effect of Intermittent Craniospinal Irradiation and Intrathecal Chemotherapy for Overt Meningeal Leukemia
- In Ah Kim, Ihl Bhong Choi, Su Mi Chung, Kyung Sub Shinn
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Radiat Oncol J. 1993;11(2):403-410.
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Between 1988 and 1992, seven patients with overt meningeal leukemia who had received adequate central nervous system (CNS) prophylaxis were treated with intermittent craniospinal irradiation and intrathecal methotrexate(IIIC).
Follow-up time ranged from 8 months to 41 months with median of 20 months. Three of 7 patients developed subsequent CNS relapse. CNS remission durations were 8, 9, 13, 20, 28, 34, 36... |
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- The Role of Conservative Surgery and Radiation Therapy for the Extremity Soft Tissue Sarcomas
- Woo Cheol Kim, Chang Ok Suh, Gwi Eon Kim, Kwang Hwa Park, Dong Hwan Shin, Kyung Hee Lee
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Radiat Oncol J. 1993;11(2):411-420.
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A total of 44 patients with extremity soft tissue sarcomas had received conservative surgery and radiation therapy in the Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine between Jan. 1980 and Dec. 1990. Initial surgical treatment consisted of intracapsular excision in 33 patients(75%), marginal excision in 9 patients, and wide excision in two patients.
Total radiation doses... |
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- Verification of Dose Distribution for Stereotactic Radiosurgery with a Linear Accelerator
- Kyung Ran Park, Kye Jun Kim, Sung Sil Chu, Jong Young Lee, Chul Woo Joh, Chang Geol Lee, Chang Ok Suh, Gwi Eon Kim
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Radiat Oncol J. 1993;11(2):421-430.
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The calculation of dose distribution in multiple arc stereotactic radiotherapy is a three-dimensional problem and, therefore, the three-dimensional dose calculation algorithm is important and the algorithm's accuracy and reliability should be confirmed experimentally. The aim of this study is to verify the dose distribution of stereotactic radiosurgery experimentally and to investigate the effect of the beam quality, the number of... |
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- Dose Distributions for LINAC Radiosurgery with Dynamically Shaping Fields
- Tae Suk Suh, Sei Chul Yoon, Moon Chan Kim, Hong Seok Jang, Yong Whee Bahk, Kyung Sub Shinn, Charn Il Park, Sung Whan Ha, Wee Saing Kang
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Radiat Oncol J. 1993;11(2):431-438.
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An important problem in radiosurgery is the utilization of the proper beam parameters, to which dose shape is sensitive. Streotactic radiosurgery techniques for a linear accelerator typically, use circular radiation fields with multiple arcs to produce an spherical radiation distribution. Target volumes are irregular in shape for a certain case, and spherical distributions can irradiate normal tissues to high dose... |
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- Selective Beam Shielding Method of Gamma-Knife Unit Using Various Plugging Patterns
- Geon Ho Jang, Young Jin Lim, Dong Oh Shin, Doo Ho Choi, Seong Eon Hong, Won Leem
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Radiat Oncol J. 1993;11(2):439-448.
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The B-type gamma knife unit was installed at Kyung-Hee University Hospital in March 1992. The selective beam plugging method can be used to reduce the low percentage isodose profiles of normal sensitive organ and to codify the isodose cuties of treatment volume for better shaping of the target volume. For representing the changes of the law percentage isodose profiles, the... |
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- The Enhancement of Skin Sparing by Tray Materials for High Energy Photon Beam
- Sung Sil Chu, Chang Geol Lee, Gwi Eon Kim
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Radiat Oncol J. 1993;11(2):449-454.
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The skin sparing effect associated with high energy x-ray or gamma ray beams may be reduce or lost under certain conditions of treatment. Current trends in using large fields. Shield carrying trays, compensating filters, and isocentric methods of treatment have posed problems of increased skin dose which sometimes become a limiting factor in giving adquate tumor doses. We used the... |
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- Dose Characteristics for IORT Applicator of ML-15MDX Electron Beam
- Tae Jin Choi, Ho Joon Lee, Yeung Ae Kim, Jin Hee Kim, Ok Bae Kim
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Radiat Oncol J. 1993;11(2):455-461.
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Experimental measurements of dose characteristics with pentagonal applicator at nominal energy of 4, 6, 9, 12 and 15 MeV electron beam were performed for intraoperative radiotherapy (IORT) in ML-15MDX linear accelerator. This paper presents the percent depth dose, surface dose, beam flatness and output factors of using the IORT applicator in different electron beam energy. The output factor showed as... |
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