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Table of Contents | September, 2014  Vol. 32  No.3 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Mechanisms of radiation-induced normal tissue toxicity and implications for future clinical trials
Jae Ho Kim, Kenneth A. Jenrow, Stephen L. Brown
Radiat Oncol J. 2014;32(3):103-115.   Published online September 30, 2014

To summarize current knowledge regarding mechanisms of radiation-induced normal tissue injury and medical countermeasures available to reduce its severity. Advances in radiation delivery using megavoltage and intensity-modulated radiation therapy have permitted delivery of higher doses of radiation to well-defined tumor target tissues. Injury to critical normal tissues and organs, however, poses substantial risks in the curative treatment of cancers, especially...

Original Articles
Clinical Investigations
Fate of pulmonary nodules detected by computer-aided diagnosis and physician review on the computed tomography simulation images for hepatocellular carcinoma
Hyojung Park, Jin-Sung Kim, Hee Chul Park, Dongryul Oh
Radiat Oncol J. 2014;32(3):116-124.   Published online September 30, 2014
Purpose

To investigate the frequency and clinical significance of detected incidental lung nodules found on computed tomography (CT) simulation images for hepatocellular carcinoma (HCC) using computer-aided diagnosis (CAD) and a physician review.

Materials and Methods

Sixty-seven treatment-naïve HCC patients treated with transcatheter arterial chemoembolization and radiotherapy (RT) were included for the study. Portal phase of simulation CT images was used for CAD analysis...

Postoperative radiotherapy in salivary ductal carcinoma: a single institution experience
Tae Hyung Kim, Mi Sun Kim, Seo Hee Choi, Yang Gun Suh, Yoon Woo Koh, Se Hun Kim, Eun Chang Choi, Ki Chang Keum
Radiat Oncol J. 2014;32(3):125-131.   Published online September 30, 2014
Purpose

We reviewed treatment outcomes and prognostic factors for patients with salivary ductal carcinoma (SDC) treated with surgery and postoperative radiotherapy from 2005 to 2012.

Materials and Methods

A total of 16 patients were identified and 15 eligible patients were included in analysis. Median age was 61 years (range, 40 to 71 years) and 12 patients (80%) were men. Twelve patients (80%) had...

Clinical outcomes after sentinel lymph node biopsy in clinically node-negative breast cancer patients
Hee Ji Han, Ju Ree Kim, Hee Rim Nam, Ki Chang Keum, Chang Ok Suh, Yong Bae Kim
Radiat Oncol J. 2014;32(3):132-137.   Published online September 30, 2014
Purpose

To evaluate non-sentinel lymph node (LN) status after sentinel lymph node biopsy (SNB) in patients with breast cancer and to identify the predictive factors for disease failure.

Materials and Methods

From January 2006 to December 2007, axillary lymph node (ALN) dissection after SNB was performed for patients with primary invasive breast cancer who had no clinical evidence of LN metastasis. A total...

Outcome of postoperative radiotherapy following radical prostatectomy: a single institutional experience
Sea-Won Lee, Tae-Kon Hwang, Sung-Hoo Hong, Ji-Youl Lee, Mi Joo Chung, Song Mi Jeong, Sung Hwan Kim, Jong Hoon Lee, Hong Seok Jang, Sei Chul Yoon
Radiat Oncol J. 2014;32(3):138-146.   Published online September 30, 2014
Purpose

This single institutional study is aimed to observe the outcome of patients who received postoperative radiotherapy after radical prostatectomy.

Materials and Methods

A total of 59 men with histologically identified prostate adenocarcinoma who had received postoperative radiation after radical prostatectomy from August 2005 to July 2011 in Seoul St. Mary's Hospital of the Catholic University of Korea, was included. They received 45-50...

The single institutional outcome of postoperative radiotherapy and concurrent chemoradiotherapy in resected non-small cell lung cancer
Hyo Chun Lee, Yeon Sil Kim, Se Jin Oh, Yun Hee Lee, Dong Soo Lee, Jin Ho Song, Jin Hyung Kang, Jae Kil Park
Radiat Oncol J. 2014;32(3):147-155.   Published online September 30, 2014
Purpose

This study was conducted to observe the outcomes of postoperative radiotherapy (PORT) with or without concurrent chemotherapy in resected non-small cell lung cancer (NSCLC) in single institution.

Materials and Methods

From 2002 to 2013, 78 patients diagnosed with NSCLC after curative resection were treated with radiotherapy alone (RT, n = 48) or concurrent chemoradiation (CCRT, n = 30). The indications of adjuvant...

The safety and efficacy of EGF-based cream for the prevention of radiotherapy-induced skin injury: results from a multicenter observational study
Hyun-Cheol Kang, Seung-Do Ahn, Doo-Ho Choi, Min Kyu Kang, Woong-Ki Chung, Hong-Gyun Wu
Radiat Oncol J. 2014;32(3):156-162.   Published online September 30, 2014
Purpose

This study was designed to evaluate the efficacy and safety of topically applied recombinant human epidermal growth factor (rhEGF) for the prevention of radiation-induced dermatitis in cancer patients.

Materials and Methods

From December 2010 to April 2012, a total of 1,172 cancer patients who received radiotherapy (RT) of more than 50 Gy were prospectively enrolled and treated with EGF-based cream. An acute...

Outcomes of stereotactic body radiotherapy for unresectable primary or recurrent cholangiocarcinoma
Da Hoon Jung, Mi-Sook Kim, Chul Koo Cho, Hyung Jun Yoo, Won Il Jang, Young Seok Seo, Eun Kyung Paik, Kum Bae Kim, Chul Ju Han, Sang Bum Kim
Radiat Oncol J. 2014;32(3):163-169.   Published online September 30, 2014
Purpose

To report the results of stereotactic body radiotherapy (SBRT) for unresectable primary or recurrent cholangiocarcinoma.

Materials and Methods

From January 2005 through August 2013, 58 patients with unresectable primary (n = 28) or recurrent (n = 30) cholangiocarcinoma treated by SBRT were retrospectively analyzed. The median prescribed dose was 45 Gy in 3 fractions (range, 15 to 60 Gy in 1-5 fractions)....

Three-dimensional conformal radiotherapy for portal vein tumor thrombosis alone in advanced hepatocellular carcinoma
Ju Hye Lee, Dong Hyun Kim, Yong Kan Ki, Ji Ho Nam, Jeong Heo, Hyun Young Woo, Dong Won Kim, Won Taek Kim
Radiat Oncol J. 2014;32(3):170-178.   Published online September 30, 2014
Purpose

We sought to evaluate the clinical outcomes of 3-dimensional conformal radiation therapy (3D-CRT) for portal vein tumor thrombosis (PVTT) alone in patients with advanced hepatocellular carcinoma.

Materials and Methods

We retrospectively analyzed data on 46 patients who received 3D-CRT for PVTT alone between June 2002 and December 2011. Response was evaluated following the Response Evaluation Criteria in Solid Tumors. Prognostic factors and...

Long-term tolerance and outcomes for dose escalation in early salvage post-prostatectomy radiation therapy
Joseph J. Safdieh, David Schwartz, Joseph Weiner, Jeffrey P. Weiss, Justin Rineer, Isaac Madeb, Marvin Rotman, David Schreiber
Radiat Oncol J. 2014;32(3):179-186.   Published online September 30, 2014
Purpose

To study the long-term outcomes and tolerance in our patients who received dose escalated radiotherapy in the early salvage post-prostatectomy setting.

Materials and Methods

The medical records of 54 consecutive patients who underwent radical prostatectomy subsequently followed by salvage radiation therapy (SRT) to the prostate bed between 2003-2010 were analyzed. Patients included were required to have a pre-radiation prostate specific antigen level...

Treatment outcome of localized prostate cancer by 70 Gy hypofractionated intensity-modulated radiotherapy with a customized rectal balloon
Hyunjung Kim, Jun Won Kim, Sung Joon Hong, Koon Ho Rha, Chang-Geol Lee, Seung Choul Yang, Young Deuk Choi, Chang-Ok Suh, Jaeho Cho
Radiat Oncol J. 2014;32(3):187-197.   Published online September 30, 2014
Purpose

We aimed to analyze the treatment outcome and long-term toxicity of 70 Gy hypofractionated intensity-modulated radiotherapy (IMRT) for localized prostate cancer using a customized rectal balloon.

Materials and Methods

We reviewed medical records of 86 prostate cancer patients who received curative radiotherapy between January 2004 and December 2011 at our institution. Patients were designated as low (12.8%), intermediate (20.9%), or high risk...

Effects of total body irradiation-based conditioning on allogeneic stem cell transplantation for pediatric acute leukemia: a single-institution study
Jongmoo Park, Eun Kyung Choi, Jong Hoon Kim, Sang-wook Lee, Si Yeol Song, Sang Min Yoon, Young Seok Kim, Su Ssan Kim, Jin-hong Park, Jaehyeon Park, Seung Do Ahn
Radiat Oncol J. 2014;32(3):198-207.   Published online September 30, 2014
Purpose

To evaluate the effects of total body irradiation (TBI), as a conditioning regimen prior to allogeneic stem cell transplantation (allo-SCT), in pediatric acute leukemia patients.

Materials and Methods

From January 2001 to December 2011, 28 patients, aged less than 18 years, were treated with TBI-based conditioning for allo-SCT in our institution. Of the 28 patients, 21 patients were diagnosed with acute lymphoblastic...

Case Report
Significant fibrosis after radiation therapy in a patient with Marfan syndrome
Eva M. Suarez, Rebecca J. Knackstedt, Joseph M. Jenrette
Radiat Oncol J. 2014;32(3):208-212.   Published online September 30, 2014

Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. It has been suggested that plasma transforming growth factor...

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