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Table of Contents | September, 2015  Vol. 33  No.3 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Image-guided radiation therapy in lymphoma management
Tony Eng, Chul S. Ha
Radiat Oncol J. 2015;33(3):161-171.   Published online September 30, 2015

Image-guided radiation therapy (IGRT) is a process of incorporating imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), Positron emission tomography (PET), and ultrasound (US) during radiation therapy (RT) to improve treatment accuracy. It allows real-time or near real-time visualization of anatomical information to ensure that the target is in its position as planned. In addition, changes in...

Original Articles
Clinical Investigation
Clinical outcomes of synchronous head and neck and esophageal cancer
Jae Won Park, Sang-wook Lee
Radiat Oncol J. 2015;33(3):172-178.   Published online September 30, 2015
Purpose

To investigate clinical outcomes of synchronous head and neck and esophageal cancer (SHNEC).

Materials and Methods

We retrospectively reviewed 27 SHNEC patients treated with curative intent at a single institution. The treatment modality for individual cases was usually determined on a case by case basis.

Results

The median follow-up duration for the surviving patients was 28.2 months. The most common site of head and...

Prognostic value of pretreatment 18F-FDG PET-CT in radiotherapy for patients with hepatocellular carcinoma
In Young Jo, Seok-Hyun Son, Myungsoo Kim, Soo Yoon Sung, Yong Kyun Won, Hye Jin Kang, So Jung Lee, Yong-An Chung, Jin Kyoung Oh, Chul-Seung Kay
Radiat Oncol J. 2015;33(3):179-187.   Published online September 30, 2015
Purpose

The purpose of this study was to investigate the predictable value of pretreatment 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) in radiotherapy (RT) for patients with hepatocellular carcinoma (HCC) or portal vein tumor thrombosis (PVTT).

Materials and Methods

We conducted a retrospective analysis of 36 stage I-IV HCC patients treated with RT. 18F-FDG PET-CT was performed before RT. Treatment target was determined...

Patterns of care for patients with nasopharyngeal carcinoma (KROG 11-06) in South Korea
Soo Yoon Sung, Min Kyu Kang, Chul Seung Kay, Ki Chang Keum, Sung Hwan Kim, Yeon-Sil Kim, Won Taek Kim, Ji-Yoon Kim, Jin-Hee Kim, Sung Ho Moon, Yong Chan Ahn, Young Taek Oh, Hong-Gyun Wu, Chang-Geol Lee, Woong-Ki Chung, Kwan Ho Cho, Moon-June Cho, Jin Hwa Choi
Radiat Oncol J. 2015;33(3):188-197.   Published online September 30, 2015
Purpose

To investigate the patterns of care for patients with nasopharyngeal carcinoma (NPC) in South Korea.

Materials and Methods

A multi-institutional retrospective study was performed (Korean Radiation Oncology Group [KROG] 11-06) on a total of 1,445 patients from 15 institutions.

Results

Of the 1,445 patients, more than half were stages III (39.9%) and IV (35.8%). In addition to patterns of care, we also investigated trends...

Treatment outcomes of curative radiotherapy in patients with vulvar cancer: results of the retrospective KROG 1203 study
Youngkyong Kim, Joo-Young Kim, Ja Young Kim, Nam Kwon Lee, Jin Hee Kim, Yong Bae Kim, Young Seok Kim, Juree Kim, Yeon-Sil Kim, Dae Sik Yang, Yeon-Joo Kim
Radiat Oncol J. 2015;33(3):198-206.   Published online September 30, 2015
Purpose

We evaluated the prognostic factors and clinical outcomes of 56 patients with vulvar cancer treated with curative radiotherapy (RT) or concurrent chemoradiotherapy.

Materials and Methods

Overall survival (OS) and disease-free survival (DFS) were assessed retrospectively. Prognostic factors evaluated included age, International Federation of Gynecology and Obstetrics (FIGO) stage, TNM classification, tumor size, treatment modality, RT duration, and RT field. The association between...

Stereotactic radiosurgery for brain metastasis in non-small cell lung cancer
Yong Kyun Won, Ja Young Lee, Young Nam Kang, Ji Sun Jang, Jin-Hyoung Kang, So-Lyoung Jung, Soo Yoon Sung, In Young Jo, Hee Hyun Park, Dong-Soo Lee, Ji Hyun Chang, Yun Hee Lee, Yeon-Sil Kim
Radiat Oncol J. 2015;33(3):207-216.   Published online September 30, 2015
Purpose

Stereotactic radiosurgery (SRS) has been introduced for small-sized single and oligo-metastases in the brain. The aim of this study is to assess treatment outcome, efficacy, and prognostic variables associated with survival and intracranial recurrence.

Materials and Methods

This study retrospectively reviewed 123 targets in 64 patients with non-small cell lung cancer (NSCLC) treated with SRS between January 2006 and December 2012. Treatment...

Clinical outcomes of stereotactic body radiotherapy for spinal metastases from hepatocellular carcinoma
Eonju Lee, Tae Gyu Kim, Hee Chul Park, Jeong Il Yu, Do Hoon Lim, Heerim Nam, Hyebin Lee, Joon Hyeok Lee
Radiat Oncol J. 2015;33(3):217-225.   Published online September 30, 2015
Purpose

To investigate the outcomes of patients with spinal metastases from hepatocellular carcinoma (HCC), who were treated by stereotactic body radiotherapy (SBRT).

Materials and Methods

This retrospective study evaluated 23 patients who underwent SBRT from October 2008 to August 2012 for 36 spinal metastases from HCC. SBRT consisted of approximately 2 fractionation schedules, which were 18 to 40 Gy in 1 to 4...

Physics Contribution
Feasibility of normal tissue dose reduction in radiotherapy using low strength magnetic field
Nuri Hyun Jung, Youngseob Shin, In-Hye Jung, Jungwon Kwak
Radiat Oncol J. 2015;33(3):226-232.   Published online September 30, 2015
Purpose

Toxicity of mucosa is one of the major concerns of radiotherapy (RT), when a target tumor is located near a mucosal lined organ. Energy of photon RT is transferred primarily by secondary electrons. If these secondary electrons could be removed in an internal cavity of mucosal lined organ, the mucosa will be spared without compromising the target tumor dose. The...

Dosimetric comparison of volumetric modulated arc therapy with robotic stereotactic radiation therapy in hepatocellular carcinoma
Eun Kyung Paik, Mi-Sook Kim, Chul Won Choi, Won Il Jang, Sung Hyun Lee, Sang Hyoun Choi, Kum Bae Kim, Dong Han Lee
Radiat Oncol J. 2015;33(3):233-241.   Published online September 30, 2015
Purpose

To compare volumetric modulated arc therapy of RapidArc with robotic stereotactic body radiation therapy (SBRT) of CyberKnife in the planning and delivery of SBRT for hepatocellular carcinoma (HCC) treatment by analyzing dosimetric parameters.

Materials and Methods

Two radiation treatment plans were generated for 29 HCC patients, one using Eclipse for the RapidArc plan and the other using Multiplan for the CyberKnife plan....

Influence of different boost techniques on radiation dose to the left anterior descending coronary artery
Kawngwoo Park, Yongha Lee, Jihye Cha, Sei Hwan You, Sunghyun Kim, Jong Young Lee
Radiat Oncol J. 2015;33(3):242-249.   Published online September 30, 2015
Purpose

The purpose of this study is to compare the dosimetry of electron beam (EB) plans and three-dimensional helical tomotherapy (3DHT) plans for the patients with left-sided breast cancer, who underwent breast conserving surgery.

Materials and Methods

We selected total of 15 patients based on the location of tumor, as following subsite: subareolar, upper outer, upper inner, lower lateral, and lower medial quadrants....

Comparison between audio-only and audiovisual biofeedback for regulating patients' respiration during four-dimensional radiotherapy
Jesang Yu, Ji Hoon Choi, Sun Young Ma, Tae Sig Jeung, Sangwook Lim
Radiat Oncol J. 2015;33(3):250-255.   Published online September 30, 2015
Purpose

To compare audio-only biofeedback to conventional audiovisual biofeedback for regulating patients' respiration during four-dimensional radiotherapy, limiting damage to healthy surrounding tissues caused by organ movement.

Materials and Methods

Six healthy volunteers were assisted by audiovisual or audio-only biofeedback systems to regulate their respirations. Volunteers breathed through a mask developed for this study by following computer-generated guiding curves displayed on a screen, combined...

Biology Contribution
Radioprotective effect of mefenamic acid against radiation-induced genotoxicity in human lymphocytes
Seyed Jalal Hosseinimehr, Reyhaneh Nobakht, Arash Ghasemi, Tayyeb Allahverdi Pourfallah
Radiat Oncol J. 2015;33(3):256-260.   Published online September 30, 2015
Purpose

Mefenamic acid (MEF) as a non-steroidal anti-inflammatory drug is used as a medication for relieving of pain and inflammation. Radiation-induced inflammation process is involved in DNA damage and cell death. In this study, the radioprotective effect of MEF was investigated against genotoxicity induced by ionizing radiation in human blood lymphocytes.

Materials and Methods

Peripheral blood samples were collected from human volunteers and...

Case Report
A case report of a patient with squamous cell carcinoma of the face irradiated using a stereotactic technique
Antonio Pontoriero, Giuseppe Iatì, Stefano Pergolizzi
Radiat Oncol J. 2015;33(3):261-264.   Published online September 30, 2015

External beam radiotherapy can be used to treat cutaneous squamous cell carcinomas (SCC). Acute skin toxicity is the most common adverse event. In this case study we report on an elderly patient with nasal root cutaneous SCC treated with stereotactic technique using a dedicated linear accelerator (CyberKnife system). Grade 3 skin toxicity was observed but it was resolved after 6...

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