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Table of Contents | December, 2015  Vol. 33  No.4 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Radiobiological mechanisms of stereotactic body radiation therapy and stereotactic radiation surgery
Mi-Sook Kim, Wonwoo Kim, In Hwan Park, Hee Jong Kim, Eunjin Lee, Jae-Hoon Jung, Lawrence Chinsoo Cho, Chang W. Song
Radiat Oncol J. 2015;33(4):265-275.   Published online December 30, 2015

Despite the increasing use of stereotactic body radiation therapy (SBRT) and stereotactic radiation surgery (SRS) in recent years, the biological base of these high-dose hypo-fractionated radiotherapy modalities has been elusive. Given that most human tumors contain radioresistant hypoxic tumor cells, the radiobiological principles for the conventional multiple-fractionated radiotherapy cannot account for the high efficacy of SBRT and SRS. Recent emerging...

Original Articles
Clinical Investigation
Treatment outcome of hepatic re-irradiation in patients with hepatocellular carcinoma
Seung Won Seol, Jeong Il Yu, Hee Chul Park, Do Hoon Lim, Dongryul Oh, Jae Myoung Noh, Won Kyung Cho, Seung Woon Paik
Radiat Oncol J. 2015;33(4):276-283.   Published online December 30, 2015
Purpose

We evaluated the efficacy and toxicity of repeated high dose 3-dimensional conformal radiation therapy (3D-CRT) for patients with unresectable hepatocellular carcinoma.

Materials and Methods

Between 1998 and 2011, 45 patients received hepatic re-irradiation with high dose 3D-CRT in Samsung Medical Center. After excluding two ineligible patients, 43 patients were retrospectively reviewed. RT was delivered with palliative or salvage intent, and equivalent dose...

Definitive radiotherapy with or without chemotherapy for clinical stage T4N0-1 non-small cell lung cancer
Yeon Joo Kim, Si Yeol Song, Seong-Yun Jeong, Sang We Kim, Jung-Shin Lee, Su Ssan Kim, Wonsik Choi, Eun Kyung Choi
Radiat Oncol J. 2015;33(4):284-293.   Published online December 30, 2015
Purpose

To determine failure patterns and survival outcomes of T4N0-1 non-small cell lung cancer (NSCLC) treated with definitive radiotherapy.

Materials and Methods

Ninety-five patients with T4N0-1 NSCLC who received definitive radiotherapy with or without chemotherapy from May 2003 to October 2014 were retrospectively reviewed. The standard radiotherapy scheme was 66 Gy in 30 fractions. The main concurrent chemotherapy regimen was 50 mg/m2 weekly...

Concurrent chemoradiotherapy improves survival outcome in muscle-invasive bladder cancer
Sang Jun Byun, Jin Hee Kim, Young Kee Oh, Byung Hoon Kim
Radiat Oncol J. 2015;33(4):294-300.   Published online December 30, 2015
Purpose

To evaluate survival rates and prognostic factors related to treatment outcomes after bladder preserving therapy including transurethral resection of bladder tumor, radiotherapy (RT) with or without concurrent chemotherapy in bladder cancer with a curative intent.

Materials and Methods

We retrospectively studied 50 bladder cancer patients treated with bladder-preserving therapy at Keimyung University Dongsan Medical Center from January 1999 to December 2010. Age...

Prognostic factors in breast cancer with extracranial oligometastases and the appropriate role of radiation therapy
Gyu Sang Yoo, Jeong Il Yu, Won Park, Seung Jae Huh, Doo Ho Choi
Radiat Oncol J. 2015;33(4):301-309.   Published online December 30, 2015
Purpose

To identify prognostic factors for disease progression and survival of patients with extracranial oligometastatic breast cancer (EOMBC), and to investigate the role of radiation therapy (RT) for metastatic lesions.

Materials and Methods

We retrospectively reviewed the medical records of 50 patients who had been diagnosed with EOMBC following standard treatment for primary breast cancer initially, and received RT for metastatic lesions, with...

Radiotherapy as an effective treatment modality for follicular lymphoma: a single institution experience
Seo Hee Choi, Jaeho Cho, Jin Seok Kim, June-Won Cheong, Chang-Ok Suh
Radiat Oncol J. 2015;33(4):310-319.   Published online December 30, 2015
Purpose

Follicular lymphoma (FL) is an indolent non-Hodgkin's lymphoma that is highly sensitive to radiotherapy (RT). However, the effectiveness of RT has not been well established. We reviewed our experiences to assess the role of RT for FL and analyze treatment results.

Materials and Methods

Retrospective analysis was done on 29 patients who received first RT between January 2003 and August 2013. Of...

Feasibility and response of helical tomotherapy in patients with metastatic colorectal cancer
Sun Hyun Bae, Seong Kwon Moon, Yong Ho Kim, Kwang Hwan Cho, Eung Jin Shin, Moon Sung Lee, Chang Beom Ryu, Bong Min Ko, Jina Yun
Radiat Oncol J. 2015;33(4):320-327.   Published online December 30, 2015
Purpose

To investigate the treatment outcome and the toxicity of helical tomotherapy (HT) in patients with metastatic colorectal cancer (mCRC).

Materials and Methods

We retrospectively reviewed 18 patients with 31 lesions from mCRC treated with HT between 2009 and 2013. The liver (9 lesions) and lymph nodes (9 lesions) were the most frequent sites. The planning target volume (PTV) ranged from 12 to...

Biology Contribution
Met inactivation by S-allylcysteine suppresses the migration and invasion of nasopharyngeal cancer cells induced by hepatocyte growth factor
Oyeon Cho, Hye-Sook Hwang, Bok-Soon Lee, Young-Taek Oh, Chul-Ho Kim, Mison Chun
Radiat Oncol J. 2015;33(4):328-336.   Published online December 30, 2015
Purpose

Past studies have reported that S-allylcysteine (SAC) inhibits the migration and invasion of cancer cells through the restoration of E-cadherin, the reduction of matrix metalloproteinase (MMP) and Slug protein expression, and inhibition of the production of reactive oxygen species (ROS). Furthermore, evidence is emerging that shows that ROS induced by radiation could increase Met activation. Following on these reports of...

Physics Contribution
The first private-hospital based proton therapy center in Korea; status of the Proton Therapy Center at Samsung Medical Center
Kwangzoo Chung, Youngyih Han, Jinsung Kim, Sung Hwan Ahn, Sang Gyu Ju, Sang Hoon Jung, Yoonsun Chung, Sungkoo Cho, Kwanghyun Jo, Eun Hyuk Shin, Chae-Seon Hong, Jung Suk Shin, Seyjoon Park, Dae-Hyun Kim, Hye Young Kim, Boram Lee, Gantaro Shibagaki, Hideki Nonaka, Kenzo Sasai, Yukio Koyabu, Changhoon Choi, Seung Jae Huh, Yong Chan Ahn, Hong Ryull Pyo, Do Hoon Lim, Hee Chul Park, Won Park, Dong Ryul Oh, Jae Myung Noh, Jeong Il Yu, Sanghyuk Song, Ji Eun Lee, Bomi Lee, Doo Ho Choi
Radiat Oncol J. 2015;33(4):337-343.   Published online December 30, 2015
Purpose

The purpose of this report is to describe the proton therapy system at Samsung Medical Center (SMC-PTS) including the proton beam generator, irradiation system, patient positioning system, patient position verification system, respiratory gating system, and operating and safety control system, and review the current status of the SMC-PTS.

Materials and Methods

The SMC-PTS has a cyclotron (230 MeV) and two treatment rooms:...

Case Report
Neck muscle atrophy and soft-tissue fibrosis after neck dissection and postoperative radiotherapy for oral cancer
Jinu Kim, Eun Seow Shin, Jeong Eon Kim, Sang Pil Yoon, Young Suk Kim
Radiat Oncol J. 2015;33(4):344-349.   Published online December 30, 2015

Late complications of head and neck cancer survivors include neck muscle atrophy and soft-tissue fibrosis. We present an autopsy case of neck muscle atrophy and soft-tissue fibrosis (sternocleidomastoid, omohyoid, digastric, sternohyoid, sternothyroid, and platysma muscles) within the radiation field after modified radical neck dissection type I and postoperative radiotherapy for floor of mouth cancer. A 70-year-old man underwent primary tumor...

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