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Table of Contents | June, 2018  Vol. 36  No.2 Previous Issue | Next Issue | Archive
In this issue:




Review Article
Radiation induced secondary malignancies: a review article
Chinna Babu Dracham, Abhash Shankar, Renu Madan
Radiat Oncol J. 2018;36(2):85-94.   Published online June 29, 2018
Radiation-induced second malignancies (RISM) is one of the important late side effects of radiation therapy and has an impact on optimal treatment decision-making. Many factors contribute to the development of RISM such as age at radiation, dose and volume of irradiated area, type of irradiated organ and tissue, radiation technique and individual and family history of cancer. Exact mechanism of...
Original Articles
Prognostic value of FDG PET/CT during radiotherapy in head and neck cancer patients
Suzy Kim, Sowon Oh, Jin Soo Kim, Yu Kyeong Kim, Kwang Hyun Kim, Do Hoon Oh, Dong-Han Lee, Woo-Jin Jeong, Young Ho Jung
Radiat Oncol J. 2018;36(2):95-102.   Published online June 29, 2018

Purpose: To evaluate the prognostic value of 18F-fluorodeoxyglucose positron-emission tomography (FDG PET) with computed tomography (CT) before and during radiotherapy (RT) in patients with head and neck cancer. Methods: Twenty patients with primary head and neck squamous cell carcinoma were enrolled in this study, of whom 6 had oropharyngeal cancer, 10 had hypopharyngeal cancer, and 4 had laryngeal cancer. Fifteen...
Treatment outcomes of radiotherapy for anaplastic thyroid cancer
Jong Won Park, Seo Hee Choi, Hong In Yoon, Jeongshim Lee, Tae Hyung Kim, Jun Won Kim, Ik Jae Lee
Radiat Oncol J. 2018;36(2):103-113.   Published online June 29, 2018

Purpose: Anaplastic thyroid cancer (ATC) is a rare tumor with a lethal clinical course despite aggressive multimodal therapy. Intensity-modulated radiotherapy (IMRT) may achieve a good therapeutic outcome in ATC patients, and the role of IMRT should be assessed. We retrospectively reviewed outcomes for ATC treated with three-dimensional conformal radiotherapy (3D-CRT) or IMRT to determine the optimal treatment option and explore...
Maximum diameter versus volumetric assessment for the response evaluation of vestibular schwannomas receiving stereotactic radiotherapy
Youngmin Choi, Sungmin Kim, Dong-Won Kwak, Hyung-Sik Lee, Myung-Koo Kang, Dong-Kun Lee, Won-Joo Hur
Radiat Oncol J. 2018;36(2):114-121.   Published online June 29, 2018

Purpose: To explore the feasibility of maximum diameter as a response assessment method for vestibular schwannomas (VS) after stereotactic radiosurgery or fractionated stereotactic radiotherapy (RT), we analyzed the concordance of RT responses between maximum diameters and volumetric measurements. Materials and Methods: Forty-two patients receiving curative stereotactic radiosurgery or fractionated stereotactic RT for VS were analyzed retrospectively. Twelve patients were excluded: 4 did not...
Positional uncertainties of cervical and upper thoracic spine in stereotactic body radiotherapy with thermoplastic mask immobilization
Seung Hyuck Jeon, Jin Ho Kim
Radiat Oncol J. 2018;36(2):122-128.   Published online June 29, 2018

Purpose: To investigate positional uncertainty and its correlation with clinical parameters in spine stereotactic body radiotherapy (SBRT) using thermoplastic mask (TM) immobilization. Materials and Methods: A total of 21 patients who underwent spine SBRT for cervical or upper thoracic spinal lesions were retrospectively analyzed. All patients were treated with image guidance using cone beam computed tomography (CBCT) and 4 degrees-of-freedom (DoF)...
Is higher dose always the right answer in stereotactic body radiation therapy for small hepatocellular carcinoma?
Kyung Hwa Lee, Jeong Il Yu, Hee Chul Park, Su Yeon Park, Jung Suk Shin, Eun Hyuk Shin, Sungkoo Cho, Sang Hoon Jung, Young Yih Han, Do Hoon Lim
Radiat Oncol J. 2018;36(2):129-138.   Published online June 29, 2018

Purpose: This study was conducted to compare clinical outcomes and treatment-related toxicities after stereotactic body radiation therapy (SBRT) with two different dose regimens for small hepatocellular carcinomas (HCC) ≤3 cm in size. Materials and Methods: We retrospectively reviewed 44 patients with liver-confined HCC treated between 2009 and 2014 with SBRT. Total doses of 45 Gy (n = 10) or 60...
External validation of IBTR! 2.0 nomogram for prediction of ipsilateral breast tumor recurrence
Byung Min Lee, Jee Suk Chang, Young Up Cho, Seho Park, Hyung Seok Park, Jee Ye Kim, Joo Hyuk Sohn, Gun Min Kim, Ja Seung Koo, Ki Chang Keum, Chang-Ok Suh, Yong Bae Kim
Radiat Oncol J. 2018;36(2):139-146.   Published online June 29, 2018

Purpose: IBTR! 2.0 nomogram is web-based nomogram that predicts ipsilateral breast tumor recurrence (IBTR). We aimed to validate the IBTR! 2.0 using an external data set. Materials and Methods: The cohort consisted of 2,206 patients, who received breast conserving surgery and radiation therapy from 1992 to 2012 at our institution, where wide surgical excision is been routinely performed. Discrimination and calibration...
Adjuvant external beam radiation and brachytherapy for vaginal resection margin positive cervical cancer
Donghyun Kim, Yongkan Ki, Wontaek Kim, Dahl Park, Joohye Lee, Jayoung Lee, Hosang Jeon, Jiho Nam
Radiat Oncol J. 2018;36(2):147-152.   Published online June 29, 2018

Purpose: To evaluate the treatment outcomes of adjuvant external beam radiation therapy (EBRT) and vaginal brachytherapy (VB) following radical hysterectomy in cervical cancer patients with involved vaginal resection margin (VRM). Materials and Methods: We retrospectively reviewed the medical records of 21 patients treated with postoperative EBRT and VB for positive VRM FIGO stage IB–IIA cervical cancer between 2003 and 2015....
Clinical outcomes and prognostic factors in patients with mycosis fungoides who underwent radiation therapy in a single institution
Bum-Sup Jang, Eunji Kim, Il Han Kim, Hyun-Cheol Kang, Sung-Joon Ye
Radiat Oncol J. 2018;36(2):153-162.   Published online June 29, 2018

Purpose: We aimed to evaluate clinical outcomes including progression-free survival (PFS), overall survival (OS), partial response, and complete response in patients who underwent radiation therapy (RT) for mycosis fungoides (MF). Also, we sought to find prognostic factors for clinical outcomes. Materials and Methods: Total 19 patients confirmed with MF between 1999–2015 were retrospectively reviewed. Clinical and treatment characteristics, clinical outcomes, and...
Case Report
Merkel cell carcinoma in the community setting: a case report
Cameron M. Callaghan, Rumpa Amornmarn
Radiat Oncol J. 2018;36(2):163-170.   Published online April 12, 2018
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin initially believed to arise from the Merkel cells. In the community setting a general radiation oncologist may only encounter this pathology in a handful of cases over the course of their career. Due to the low incidence of this malignancy, few prospective randomized controlled trials have ever been...
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