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Table of Contents | September, 2018  Vol. 36  No.3 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Novel biological strategies to enhance the radiation therapeutic ratio
Jae Ho Kim, Kenneth A. Jenrow, Stephen L. Brown
Radiat Oncol J. 2018;36(3):172-181.   Published online September 30, 2018
Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted...
Original Articles
Clinical investigation
Clinical outcome of proton therapy for patients with chordomas
Sang Hee Youn, Kwan Ho Cho, Joo-Young Kim, Boram Ha, Young Kyung Lim, Jong Hwi Jeong, Sang Hyun Lee, Heon Yoo, Ho-Shin Gwak, Sang Hoon Shin, Eun Kyung Hong, Han Kyu Kim, Je Beom Hong
Radiat Oncol J. 2018;36(3):182-191.   Published online September 30, 2018

Purpose: To investigate the clinical outcome of proton therapy (PT) in patients with chordoma. Materials and Methods: Fifty-eight patients with chordoma treated with PT between June 2007 and December 2015 at the National Cancer Center, Korea, were retrospectively analyzed. The median total dose was 69.6 cobalt gray equivalent (CGE; range, 64.8 to 79.2 CGE). Local progression-free survival (LPFS), distant metastasis-free survival...
Optimal timing for salvage surgery after definitive radiotherapy in hypopharyngeal cancer
Seok-Joo Chun, Bhumsuk Keam, Dae Seog Heo, Kwang Hyun Kim, Myung-Whun Sung, Eun-Jae Chung, Ji-hoon Kim, Kyeong Cheon Jung, Jin Ho Kim, Hong-Gyun Wu
Radiat Oncol J. 2018;36(3):192-199.   Published online September 30, 2018

Purpose: Use of radiotherapy combined with chemotherapy is increasing in hypopharyngeal cancer. However, many show residual tumor after radiotherapy. Timing for treatment evaluation and salvage therapy is essential. However, optimal timing for salvage surgery has not been suggested. In this study, we tried to evaluate optimal timing for salvage surgery. Methods and Materials: Patients who were diagnosed with hypopharyngeal squamous cell...
Effectiveness and feasibility of concurrent chemoradiotherapy using simultaneous integrated boost-intensity modulated radiotherapy with and without induction chemotherapy for locally advanced pancreatic cancer
Eun Sang Oh, Tae Hyun Kim, Sang Myung Woo, Woo Jin Lee, Ju Hee Lee, Sang Hee Youn, Sung Sik Han, Sang Jae Park, Dae Yong Kim
Radiat Oncol J. 2018;36(3):200-209.   Published online September 30, 2018

Purpose: To evaluate the effectiveness and feasibility of chemoradiotherapy (CRT) using simultaneous integrated boost-intensity modulated radiotherapy (SIB-IMRT) in locally advanced pancreatic cancer (LAPC) patients. Materials and Methods: Between January 2011 and May 2015, 47 LAPC patients received CRT using SIB-IMRT. Prior to SIBIMRT, 37 patients (78.7%) received induction chemotherapy (IC-CRT group) and remaining 10 patients (21.3%) did not received induction chemotherapy...
Use of radiotherapy in patients with palliative double bypass for locally advanced pancreatic adenocarcinoma
Juan Glinka, Federico Diaz, Augusto Alva, Oscar Mazza, Rodrigo Sanchez Claria, Victoria Ardiles, Eduardo de Santibañes, Juan Pekolj, Martín de Santibañes
Radiat Oncol J. 2018;36(3):210-217.   Published online September 30, 2018

Purpose: Pancreatic cancer (PC) has not changed overall survival in recent years despite therapeutic efforts. Surgery with curative intent has shown the best long-term oncological results. However, 80%–85% of patients with these tumors are unresectable at the time of diagnosis. In those patients, first therapeutic attempts are minimally invasive or surgical procedures to alleviate symptoms. The addition of radiotherapy (RT)...
Single nucleotide polymorphism of GSTP1 and pathological complete response in locally advanced rectal cancer patients treated with neoadjuvant concomitant radiochemotherapy
Luca Nicosia, Giovanna Gentile, Chiara Reverberi, Giuseppe Minniti, Maurizio Valeriani, Vitaliana de Sanctis, Luca Marinelli, Fabiola Cipolla, Ottavia de Luca, Maurizio Simmaco, Mattia F. Osti
Radiat Oncol J. 2018;36(3):218-226.   Published online September 30, 2018

Purpose: Standard treatment for locally advanced rectal cancer consists of neoadjuvant radiochemotherapy with concomitant fluoropyrimidine or oxaliplatin and surgery with curative intent. Pathological complete response has shown to be predictive for better outcome and survival; nevertheless there are no biological or genetic factors predictive for response to treatment. We explored the correlation between the single nucleotide polymorphisms (SNPs) GSTP1 (A313G)...
Dose comparison between prescription methods according to anatomical variations in intracavitary brachytherapy for cervical cancer
Euncheol Choi, Jae Ho Kim, Ok Bae Kim, Sang Jun Byun, Jin Hee Kim, Young Kee Oh
Radiat Oncol J. 2018;36(3):227-234.   Published online September 30, 2018

Purpose: We compared how doses delivered via two-dimensional (2D) intracavitary brachytherapy (ICBT) and three-dimensional (3D) ICBT varied anatomically. Materials and Methods: A total of 50 patients who received 30 Gy of 3D ICBT after external radiotherapy (RT) were enrolled. We compared the doses of the actual 3D and 2D ICBT plans among patients grouped according to six anatomical variations: differences in...
Assessment of inter- and intra-fractional volume of bladder and body contour by mega-voltage computed tomography in helical tomotherapy for pelvic malignancy
Sunghyun Kim, Sei Hwan You, Young Ju Eum
Radiat Oncol J. 2018;36(3):235-240.   Published online September 30, 2018

Purpose: We describe the daily bladder volume change observed by mega-voltage computed tomography (MVCT) during pelvic radiotherapy with potential predictors of increased bladder volume variations. Materials and Methods: For 41 patients who received pelvic area irradiation, the volumes of bladder and pelvic body contour were measured twice a day with pre- and post-irradiation MVCT from the 1st to the 10th fraction....
Physics Contribution
Evaluation of the hybrid-dynamic conformal arc therapy technique for radiotherapy of lung cancer
Sung Joon Kim, Jeong Won Lee, Min Kyu Kang, Jae-Chul Kim, Jeong Eun Lee, Shin-Hyung Park, Mi Young Kim, Seoung-Jun Lee, Soo-Ho Moon, Byoung-Soo Ko
Radiat Oncol J. 2018;36(3):241-247.   Published online September 30, 2018

Purpose: A hybrid-dynamic conformal arc therapy (HDCAT) technique consisting of a single half-rotated dynamic conformal arc beam and static field-in-field beams in two directions was designed and evaluated in terms of dosimetric benefits for radiotherapy of lung cancer. Materials and Methods: This planning study was performed in 20 lung cancer cases treated with the VERO system (BrainLAB AG, Feldkirchen, Germany). Dosimetric...
Case Report
Impact of testicular shielding in liposarcoma to scrotum by using radio-photoluminescence glass dosimeter (RPLGD): a case report
Puntiwa Oonsiri, Kitwadee Saksornchai, Sivalee Suriyapee
Radiat Oncol J. 2018;36(3):248-253.   Published online September 30, 2018
Radiation protection in the scrotum to reduce the risk of genetic effect in the future is very important. This study aimed to measure the scrotal dose outside the treatment fields by using the radio-photoluminescence glass dosimeter (RPLGD). The characteristics of RPLGD model GD-302M were studied. Scattered dose to scrotum was measured in one liposarcoma case with the prescribed dose of...
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