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Table of Contents | June, 2019  Vol. 37  No.2 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Less is more: role of additional chemotherapy to concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal cancer management
Yong Chan Ahn
Radiat Oncol J. 2019;37(2):67-72.   Published online June 30, 2019
Concurrent chemoradiation therapy (CCRT) has played the most important and central role in the definitive therapy for the patients with locoregionally advanced stage nasopharynx cancer. The addition of induction chemotherapy (IC) or adjuvant chemotherapy (AC) to CCRT have been widely accepted with the rationale of improving distant control in the clinical practices. This review article investigated the role of IC...
Original Articles
Clinical Investigation
Prognostic factors, failure patterns and survival analysis in patients with resectable oral squamous cell carcinoma of the tongue
Kanika Sharma, Parveen Ahlawat, Munish Gairola, Sarthak Tandon, Nishtha Sachdeva, Muhammed Ismail Sharief
Radiat Oncol J. 2019;37(2):73-81.   Published online June 30, 2019

Purpose: There is sparse literature on treatment outcomes research on resectable oral tongue squamous cell carcinoma (OTSCC). The aim of this study was to measure the treatment outcomes, explore the failure patterns, and identify the potential clinicopathological prognostic factors affecting treatment outcomes for resectable OTSCC. Materials and Methods: It is a retrospective analysis of 202 patients with resectable OTSCC who underwent...
Hypofractionated radiotherapy for early glottic cancer: a retrospective interim analysis of a single institution
Jeong Won Lee, Jeong Eun Lee, Junhee Park, Jin Ho Sohn, Dongbin Ahn
Radiat Oncol J. 2019;37(2):82-90.   Published online June 30, 2019

Purpose: To evaluate the results of hypofractionated radiotherapy (HFX) for early glottic cancer. Materials and Methods: Eighty-five patients with cT1-2N0M0 squamous cell carcinoma of the glottis who had undergone HFX, performed using intensity-modulated radiotherapy (IMRT, n = 66) and three-dimensional conformal radiotherapy (3D CRT, n = 19) were analyzed. For all patients, radiotherapy was administered at 60.75 Gy in 27 fractions....
Radiotherapy for initial clinically positive internal mammary nodes in breast cancer
Jina Kim, Jee Suk Chang, Seo Hee Choi, Yong Bae Kim, Ki Chang Keum, Chang-Ok Suh, Gowoon Yang, Yeona Cho, Jun Won Kim, Ik Jae Lee
Radiat Oncol J. 2019;37(2):91-100.   Published online June 30, 2019

Purpose: Internal mammary lymph node (IMN) involvement is associated with poor prognosis in breast cancer. This study investigated the treatment outcomes of initial clinically IMN-positive breast cancer patients who received adjuvant radiotherapy (RT), including IMN irradiation, following primary breast surgery. Materials and Methods: We retrospectively reviewed data of 95 breast cancer patients with clinically detected IMNs at diagnosis treated with surgery...
Preliminary results of entire pleural intensity-modulated radiotherapy in a neoadjuvant setting for resectable malignant mesothelioma
Ji Hyun Hong, Hyo Chun Lee, Kyu Hye Choi, Seok Whan Moon, Kyung Soo Kim, Suk Hee Hong, Ju-Young Hong, Yeon-Sil Kim, Multidisciplinary Team of Lung Cancer in Seoul St. Mary’s Hospital
Radiat Oncol J. 2019;37(2):101-109.   Published online June 30, 2019

Purpose: The purpose of this study is to evaluate the safety and efficacy of the multimodality treatment with neoadjuvant intensitymodulated radiotherapy (IMRT) for resectable clinical T1-3N0-1M0 malignant pleural mesothelioma (MPM). Materials and Methods: A total of eleven patients who received neoadjuvant chemotherapy and radiotherapy between March 2016 and June 2018 were reviewed. Patients received 25 Gy in 5 fractions to entire...
Risk factors for locoregional recurrence in patients with pathologic T3N0 rectal cancer with negative resection margin treated by surgery alone
Jong Yun Baek, Jeong Il Yu, Hee Chul Park, Doo Ho Choi, Gyu Sang Yoo, Won Kyung Cho, Woo-Yong Lee, Seong Hyeon Yun, Yong Beom Cho, Yoon Ah Park, Hee Cheol Kim
Radiat Oncol J. 2019;37(2):110-116.   Published online June 30, 2019

Purpose: This study aimed to identify prognostic factors for locoregional recurrence (LRR) in pT3N0 rectal cancer patients who were treated with surgery alone and had negative resection margin including circumferential resection margin (CRM) for optimal indication of adjuvant radiotherapy. Materials and Methods: We reviewed patients with pT3N0 rectal cancer who were treated via upfront surgery and had no other adjuvant treatment...
Characterization and predictive value of volume changes of extremity and pelvis soft tissue sarcomas during radiation therapy prior to definitive wide excision
Chengcheng Gui, Carol D. Morris, Christian F. Meyer, Adam S. Levin, Deborah A. Frassica, Curtiland Deville, Stephanie A. Terezakis
Radiat Oncol J. 2019;37(2):117-126.   Published online March 28, 2019

Purpose: The purpose of this study was to characterize and evaluate the clinical significance of volume changes of soft tissue sarcomas during radiation therapy (RT), prior to definitive surgical resection. Materials and Methods: Patients with extremity or pelvis soft tissue sarcomas treated at our institution from 2013 to 2016 with RT prior to resection were identified retrospectively. Tumor volumes were measured...
Physics Contribution
Interfraction variation and dosimetric changes during image-guided radiation therapy in prostate cancer patients
Frederik Fuchs, Gregor Habl, Michal Devečka, Severin Kampfer, Stephanie E. Combs, Kerstin A. Kessel
Radiat Oncol J. 2019;37(2):127-133.   Published online March 28, 2019

Purpose: The aim of this study was to identify volume changes and dose variations of rectum and bladder during radiation therapy in prostate cancer (PC) patients. Materials and Methods: We analyzed 20 patients with PC treated with helical tomotherapy. Daily image guidance was performed. We re-contoured the entire bladder and rectum including its contents as well as the organ walls on...
Auto-segmentation of head and neck organs at risk in radiotherapy and its dependence on anatomic similarity
Anantharaman Ayyalusamy, Subramani Vellaiyan, Shanmuga Subramanian, Arivarasan Ilamurugu, Shyama Satpathy, Mohammed Nauman, Gowtham Katta, Aneesha Madineni
Radiat Oncol J. 2019;37(2):134-142.   Published online June 30, 2019

Purpose: The aim is to study the dependence of deformable based auto-segmentation of head and neck organs-at-risks (OAR) on anatomy matching for a single atlas based system and generate an acceptable set of contours. Methods: A sample of ten patients in neutral neck position and three atlas sets consisting of ten patients each in different head and neck positions were utilized...
Case Report
Clinical and radiobiological consideration of cyclical hypofractionated radiation therapy also known as QUAD Shot for neglected skin cancer disfiguring the face of a non-compliant patient who was refusing surgery and protracted radiation therapy: case report
Whoon Jong Kil, Kevin Camphausen, In Hye Cho
Radiat Oncol J. 2019;37(2):143-148.   Published online June 30, 2019
Although surgery is the mainstay of local treatment for skin cancer, definitive radiation therapy (RT) has been also applied for patients who are unable to tolerate surgery. Definitive RT regimens usually consist of daily treatment for 4–7 weeks. Such protracted daily RT regimens, however, would not be feasible for non-compliant patients or patients who are unable to make multiple daily...
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