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Table of Contents | December, 2019  Vol. 37  No.4 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Current status of proton therapy techniques for lung cancer
Youngyih Han
Radiat Oncol J. 2019;37(4):232-248.   Published online December 31, 2019
Proton beams have been used for cancer treatment for more than 28 years, and several technological advancements have been made to achieve improved clinical outcomes by delivering more accurate and conformal doses to the target cancer cells while minimizing the dose to normal tissues. The state-of-the-art intensity modulated proton therapy is now prevailing as a major treatment technique in proton...
Original Articles
Clinical Investigation
Recent trends in intensity-modulated radiation therapy use in Korea
Seung Jae Huh, Won Park, Do Ho Choi
Radiat Oncol J. 2019;37(4):249-253.   Published online December 31, 2019

Purpose: We aimed to analyze the trend in intensity-modulated radiation therapy (IMRT) use in Korea from 2011 to 2018. Materials and Methods: We collected data from the Health and Insurance Review and Assessment Service (HIRA) big data based on the National Health Insurance Service claims and reimbursements records using primary treatment planning codes (HD 041) for IMRT from 2011 to 2018....
Liver dose reduction by deep inspiration breath hold technique in right-sided breast irradiation
Gunel Haji, Ulviye Nabizade, Kamal Kazimov, Naile Guliyeva, Isa Isayev
Radiat Oncol J. 2019;37(4):254-258.   Published online December 31, 2019

Purpose: Deep inspiration breath hold (DIBH) is a well-established technique that enables efficient cardiac sparing in patients with left-sided breast cancer. The aim of the current study was to determine if DIBH is effective for reducing radiation exposure of of liver and other organs at risk in right breast radiotherapy (RT). Materials and Methods: Twenty patients with right-sided breast cancer were...
Daily localization of partial breast irradiation patients with three-dimensional ultrasound imaging
Mutlay Sayan, Irina Vergalasova, Daphne Hard, Heather Wrigth, Jessica Archambault, Havaleh Gagne, Carl Nelson, Ruth Heimann
Radiat Oncol J. 2019;37(4):259-264.   Published online December 31, 2019

Purpose: Accurate localization of the lumpectomy cavity during accelerated partial breast radiation (APBR) is essential for daily setup to ensure the prescribed dose encompasses the target and avoids unnecessary irradiation to surrounding normal tissues. Three-dimensional ultrasound (3D-US) allows direct visualization of the lumpectomy cavity without additional radiation exposure. The purpose of this study was to evaluate the feasibility of 3D-US...
Evaluation of response to stereotactic radiosurgery in patients with radioresistant brain metastases
Mutlay Sayan, Teuta Zoto Mustafayev, Bilgehan Sahin, Erva Seyma Sare Kefelioglu, Shang-Jui Wang, Varsha Kurup, Aykut Balmuk, Gorkem Gungor, Nisha Ohri, Joseph Weiner, Enis Ozyar, Banu Atalar
Radiat Oncol J. 2019;37(4):265-270.   Published online December 31, 2019

Purpose: Renal cell carcinoma (RCC) and melanoma have been considered ‘radioresistant’ due to the fact that they do not respond to conventionally fractionated radiation therapy. Stereotactic radiosurgery (SRS) provides high-dose radiation to a defined target volume and a limited number of studies have suggested the potential effectiveness of SRS in radioresistant histologies. We sought to determine the effectiveness of SRS...
Intensity-modulated radiotherapy for stage I glottic cancer: a short-term outcomes compared with three-dimensional conformal radiotherapy
Ick Joon Cho, Woong-Ki Chung, Joon Kyoo Lee, Min-Cheol Lee, Jayeong Paek, Yong-Hyub Kim, Jae-Uk Jeong, Mee Sun Yoon, Ju-Young Song, Taek-Keun Nam, Sung-Ja Ahn, Dong Hoon Lee, Tae Mi Yoon, Sang-Chul Lim
Radiat Oncol J. 2019;37(4):271-278.   Published online December 31, 2019

Purpose: To investigate the differences in treatment outcomes between two radiation techniques, intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT). Materials and Methods: We retrospectively analyzed 160 (IMRT = 23, 3DCRT = 137) patients with stage I glottic cancer treated from January 2005 through December 2016. The IMRT was performed with TomoTherapy (16 patients), volumetric-modulated arc therapy (6 patients), and step-and-shoot...
Retrospective analysis of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy of postoperative treatment for biliary tract cancer
Hyo Chun Lee, Jong Hoon Lee, Sea-Won Lee, Joo Hwan Lee, Mina Yu, Hong Seok Jang, Sung Hwan Kim
Radiat Oncol J. 2019;37(4):279-285.   Published online December 31, 2019

Purpose: This study was conducted to compare the outcome of three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for the postoperative treatment of biliary tract cancer. Materials and Methods: From February 2008 to June 2016, 57 patients of biliary tract cancer treated with curative surgery followed by postoperative 3D-CRT (n = 27) or IMRT (n = 30) were retrospectively enrolled. Results: Median...
Radiotherapy for mandibular metastases from hepatocellular carcinoma: a single institutional experience
Jongmoo Park, Sang Min Yoon
Radiat Oncol J. 2019;37(4):286-292.   Published online December 31, 2019

Purpose: A mandibular metastasis is uncommon in patients with hepatocellular carcinoma (HCC). We report the clinical features of this rare lesion and evaluate the effectiveness of radiotherapy in affected patients. Materials and Methods: We retrospectively reviewed our institutional medical records for HCC patients who received radiotherapy for bone metastasis, and included cases of mandible metastasis. The clinical features of these cases,...
Effectiveness of radiotherapy for head and neck skin cancers: a single-institution study
Jae Wang Kim, Byung Min Yun, Myoung Soo Shin, Jae Kyoung Kang, JungJu Kim, Young Suk Kim
Radiat Oncol J. 2019;37(4):293-301.   Published online December 31, 2019

Purpose: External beam radiotherapy (EBRT) is a useful option to treat head and neck skin cancer patients who are not indicated for surgery. In this study, we evaluated the treatment outcomes of EBRT in an Asian population. Materials and Methods: The records from 19 head and neck skin cancer patients (10 with squamous cell carcinoma and 9 with basal cell carcinoma)...
Case Report
Extracranial systemic antitumor response through the abscopal effect induced by brain radiation in a patient with metastatic melanoma
Mark A. D’Andrea, G. K. Reddy
Radiat Oncol J. 2019;37(4):302-308.   Published online December 31, 2019
The abscopal effect is a term that has been used to describe the phenomenon in which localized radiation therapy treatment of a tumor lesion triggers a spontaneous regression of metastatic lesion(s) at a non-irradiated distant site(s). Radiation therapy induced abscopal effects are believed to be mediated by activation and stimulation of the immune system. However, due to the brain’s distinctive...
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