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Table of Contents | March, 2021  Vol. 39  No.1 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Optimizing e-learning in oncology during the COVID-19 pandemic and beyond
Monica Malik, Deepthi Valiyaveettil, Deepa Joseph
Radiat Oncol J. 2021;39(1):1-7.   Published online December 14, 2020
The coronavirus disease 2019 (COVID-19) pandemic has profoundly impacted cancer care, research and residency training in oncology worldwide. Many countries canceled exams, shortened their residency program and medical school tenure. Traditional teaching and learning method has faced significant disruption during this time and the situation has pushed us to adapt to e-learning. Most national and international cancer meetings were converted...
Original Articles
Clinical Investigation
Atlas of sentinel lymph nodes in early breast cancer using single-photon emission computed tomography: implication for lymphatic contouring
Sergey Nikolaevich Novikov, Pavel Ivanovich Krzhivitskii, Yulia Sergeevna Melnik, Alina Albertovna Valitova, Zhanna Viktorovna Bryantseva, Irina Alexandrovna Akulova, Sergey Vasilevich Kanaev
Radiat Oncol J. 2021;39(1):8-14.   Published online March 25, 2021

Purpose: to determine the localization of sentinel lymph nodes (SLNs) in a large cohort of patients with breast cancer and validate the European Society for Therapeutic Radiology and Oncology (ESTRO), Radiation Therapy Oncology Group (RTOG), and Radiotherapy Comparative Effectiveness (RADCOMP) guidelines on regional lymph node clinical target volume (CTV-LN) delineation. Materials and Methods: A total of 254 women with cT1-3N0-1M0 breast...
A randomized prospective study comparing acute toxicity, compliance and objective response rate between simultaneous integrated boost and sequential intensity-modulated radiotherapy for locally advanced head and neck cancer
Akanksha Grover, Tej Prakash Soni, Nidhi Patni, Dinesh Kumar Singh, Naresh Jakhotia, Anil Kumar Gupta, Lalit Mohan Sharma, Shantanu Sharma, Ravindra Singh Gothwal
Radiat Oncol J. 2021;39(1):15-23.   Published online March 18, 2021

Purpose: Intensity-modulated radiotherapy (IMRT) provides higher dose to target volumes and limits the dose to normal tissues. IMRT may be applied using either simultaneous integrated boost (SIB-IMRT) or sequential boost (SEQ-IMRT) technique. The objectives of this study were to compare acute toxicity and objective response rates between SIB-IMRT and SEQ-IMRT in patients with locally advanced head and neck cancer. Materials and...
Salvage proton beam therapy for locoregional recurrence of non-small cell lung cancer
Hyunju Shin, Jae Myoung Noh, Hongryull Pyo, Yong Chan Ahn, Dongryul Oh
Radiat Oncol J. 2021;39(1):24-32.   Published online March 4, 2021

Purpose: This study aimed to evaluate the clinical outcomes and toxicities of salvage proton beam therapy (PBT) in patients with locoregional recurrent non-small cell lung cancer (NSCLC). Materials and Methods: We retrospectively reviewed 53 patients who received salvage PBT for locoregionally recurrent NSCLC between January 2016 and December 2019. The median clinical target volume (CTV) was 71.2 cm3 (range, 13.3...
Stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of liver metastases in oligometastatic patients: initial clinical experience
Gamze Ugurluer, Teuta Zoto Mustafayev, Gorkem Gungor, Banu Atalar, Ufuk Abacioglu, Meric Sengoz, Fulya Agaoglu, Gokhan Demir, Enis Ozyar
Radiat Oncol J. 2021;39(1):33-40.   Published online March 26, 2021

Purpose: We aimed to present our initial clinical experience on the implementation of a stereotactic MR-guided online adaptive radiation therapy (SMART) for the treatment of liver metastases in oligometastatic disease. Methods and Materials: Twenty-one patients (24 lesions) with liver metastasis treated with SMART were included in this retrospective study. Step-and-shoot intensity-modulated radiotherapy technique was used with daily plan adaptation. During delivery,...
Palliative treatment of Kaposi sarcoma with radiotherapy: a single center experience
Gonca Altinisik Inan, Ipek Pinar Aral, Suheyla Aytac Arslan, Yilmaz Tezcan
Radiat Oncol J. 2021;39(1):41-47.   Published online March 22, 2021

Purpose: The aim of this study is to evaluate the treatment responses of Kaposi sarcoma patients treated with radiotherapy (RT). Materials and Methods: The data of 18 patients (40 different regions) who were treated for Kaposi sarcoma in OOOO between March 23, 2010 to February 13, 2018 were evaluated retrospectively. The primary endpoint of the study was the clinical-subjective response after...
Biology Contribution
Exploring the differentially expressed genes in human lymphocytes upon response to ionizing radiation: a network biology approach
Tamizh Selvan Gnana Sekaran, Vishakh R. Kedilaya, Suchetha N. Kumari, Praveenkumar Shetty, Pavan Gollapalli
Radiat Oncol J. 2021;39(1):48-60.   Published online March 24, 2021

Purpose: The integration of large-scale gene data and their functional analysis needs the effective application of various computational tools. Here we attempted to unravel the biological processes and cellular pathways in response to ionizing radiation using a systems biology approach. Materials and Methods: Analysis of gene ontology shows that 80, 42, 25, and 35 genes have roles in the biological...
Radioprotective potential of Costus afer against the radiation-induced hematological and histopathological damage in mice
Idowu Richard Akomolafe, Naven Chetty
Radiat Oncol J. 2021;39(1):61-71.   Published online March 26, 2021

Purpose: This study investigated the possible radioprotective effect of Costus afer extract (CAE) on hematological and histopathological parameters of mice. Materials and Methods: Fifty-four male mice with mass between 37–43 g, 11–13 weeks old were used for this study. We divided the mice into six different groups containing nine animals, which were then further sub-divided into irradiated groups and...
Case Reports
Clinical behaviour and outcome in pediatric glioblastoma: current scenario
Aditya Kumar Singla, Renu Madan, Kirti Gupta, Shikha Goyal, Narendra Kumar, Sushant Kumar Sahoo, Deepak K. Uppal, Chirag K. Ahuja
Radiat Oncol J. 2021;39(1):72-77.   Published online March 30, 2021
Pediatric glioblastoma (pGBM) is a rare entity accounting for only approximately 3% of all childhood brain tumors. Treatment guidelines for pGBM have been extrapolated from those in adult glioblastoma. Rarity of pGBM and underrepresentation of pediatric population in major studies precludes from defining the ideal treatment protocol for these patients. Maximum safe resection is performed in most of the cases...
Systemic therapy augmented by radiotherapy (STAR) effect for brain metastases in a BRAF-mutated melanoma patient with prolonged survival: a case report
Agostino Cristaudo, Antonio Malorgio, Serena Medoro, Antonio Stefanelli
Radiat Oncol J. 2021;39(1):78-81.   Published online March 3, 2021
Brain metastases are common in stage IV malignant melanoma, carrying a prognosis traditionally regarded as severe, with a median survival of few months. Recently introduced systemic therapies as targeted therapy or immunotherapy have significantly improved the prognosis of metastatic melanoma. The optimal association of radiotherapy to such novel treatments has to be clarified. We report on a 43-year-old woman with...
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