Using as assay for jejunal crypt stem cell survival, dose-response curves for the reproductive capacity of crypt stem cells mouse jejunum exposed to multifractionated gamma-ray irradiation(single, 2, 3, 4, 5, 6, 7, 8, 10,12, and 16 fractions) were analyzed and single-dose survival curve of these cells was constructed. The following conclusion were drawn: 1) Survival curves for higher numbers of...

Optimal balance between control probability and risk of complication is emphasized even in present time. Although certain incidence of intestinal injury is accepted as an inevitable consequence after abdominopelvic irradiation, these complications still remain as problems. 60 mice were irradiated with 250kVp orthovoltage x-ray machine and 200 rad x5/wk regimen. Histpathologic findings of colorectum and the relationship with occult blood...

Radiation myelitis is a rather rare, but irreversible fatal complication, Etiology, pathologic change, clinical symptoms and the method of diagnosis have been studies, pathogenesis of post-irradiation myelitis and the level of tolerance dose still remain controversial. Thoracolumbar spine of 110 hybrid mice were irradiated with orthovoltage x-ray machine. Mild capillary congestion and axonal welling were observed in 1,000rad irradiated specimens were...

Hyperthermia can enhance the radiation effect as a synergistic reaction in combined X-ray irradiation and hyperthermia; hyperthermia sensitize radilresistant S-phase cells and inhibit cellular recovery from sublethal damage. We fabricated 100 watts, 2450MHz microwave applicator for hyperthermia and planned the method and condition of heating and measured the temperature by usting Agar phantom as a preliminary test. For biological examination, 102...

To know the three questions about multiple primary cancers: 1) what are the characteristics of persons having multiple primary cancer? 2) Dose presence of a single primary concer after the susceptibility to multiple primary cancers? 3) Dose the location of one multiple pripary cancer influence the site of others?, we analysed 121 cases of multiple primary malignant neoplasms registered in...

Seven patients having midline granuloma received local irradiation from March 1983 to June 1986. Clinically, all of the 7 patients had pansinusitis with necrotic destruction of the involved sites and one case revealed colonic lesion. Each of the patients received a tumor dose of 4,000 ~ 5,000 cGy/5~6wks to the upper aerodingestive tract using a 6-MV linear accelerator. Complete and partial...

From January, 1981 to December, 1985, 22 patients with locally unresectable carcininoma of the pancreas were treated in the Department of Therapeutic Radiology, Seoul National University Hospital, Radiation was given in two split courses; each consisting of 2000 cGy over two weeks sepatated by two-week rest period. 5-FU was administered on the first three days of each radiation therapy course....

To assess the effect of postoperative radiotherapy on tumor recurrence and patient survival, 133 patients who received adjuvant postoperative radiotherapy for adenocarcinoma of the rectum were retrospectively analyzed. Sixty-one percent of the patients were in stage C2 by Astler-Coller staging system. A significant statistical difference was noticed in failure rates for lymph node negative vs lymph node positive patients;26%(9/35) vs...

From Nov. 1983 through Feb. 1986, 35 patients of uterine cervical cancer were treated by external radiation therapy and intracavitary radiation therapy using Fletcher-Sult-Delclos applicator. Age of the patients ranged from 32 to 70 years (median age:53 years). All patients had follow up from 9 to 34 months and median follow up of 20 months. 4 patients were in stage...

In electron therapy, lead cutout or low-melting alloy block is used for shaping the field. Material for shaping electron field affects the output factor as well as the collimation system. The authors measured the output factors of electron beams for shaped fields from Clinac-18 using ionization chamber of Farmer type on polystyrene phantom. They analyzed the incident energy, collimation system...

Since March 1985, we have treated cancer patients with local hyperthermia using a 2,450-MHz microwave thermogenerator. Prior to clinical trail, a 2,450-MHz microwave generator remodeled from a household electric range was tested and evaluated to test its clinical applicability. We studied the thermoprofile and tried to find out suitable electric power ranges to produce optimal temperature of 42-44 degree C in...

Computed tomography(CT) adds a new dimension in the study of body contour, organs and tissues as well as various pathologic conditions. This modality provides a great degree of accuracy in radiation therapy planning(RTP). However, CT images are usually taken on a small reduced format so that possible errors can be made during inputting the CT data into an automatic planner....

In brachytherapy of uterine cervical cancer using the high dose rate remote afterloading system, it is of prime importance to determine the position of the radiation sources and to estimate the irradiation time. However, calculation with manual method is so time consuming and laborious, that authors designed a software as an aid to intracavitary radiotherapy planning using the personal computer...