PURPOSE: Paclitaxel is a chemotherapeutic agent with potent microtublue stablelizing activity that arrests cell cycle in G2-M. Because G2-M is the most radiosensitive phase of the cell cycle. Paclitaxel has potential as a cell cycle- specic radio sensitizer. This study was design to investigate the ablity of paclitaxel to increase the radiotoxicity in normal small bowl mucosa of the rat. METHODS...

Damage produced by radiation elicits a complex response in mammalian cells. Including growth rate changes and the induction of a variety of genes associated with growth control and apoptosis.At doses of 10,000 cGy or greater, the exposed indivisual was killed in a matter of minutes to a couple of days. With symptoms consistent with pathology of the central nervous system(CNS)...

PURPOSE: Chest irradiation leads to a significant cardiac injury in a number of patients. To prevent, or to reduce the risk of radiation-induced cardiac injury, pentosifylline(PTX), a haemorrheologic agent that improves the blood flow through small blood capillaries has been employed. MATERIALS AND METHODS: One hundred and eighty ICR mice were divided into three study groups : control, radiation alone, and...

PURPOSE: This study was performed to evaluate survival, failure patterns, and prognositc factors of MMR patients after radiation therapy. We also discussed the need for chemotherapy. MATERIALS AND METHODS: A retrospective analysis was done for 23 patients with MMR who were treated with radiation therapy form June 1985 to November 1992. There were 19 male and 4 female patients. The patients'...

PURPOSE: Respiratory symptoms related with malignant airway disease have been the main causes of lowered quality of life and also sometimes may be life-threatening if not properly amanged. He authors report the short-term experiences of endobronchial brachytherapy for symptomatic malignant airway obstruction using high dose rate after-loading brachytherapy unit. MATERIALS AND METHODS: Twenty-five patients with symptomatic malignant airway obstruction were treated...

PURPOSE: The authors conducted a retrospective analysis of patients with the carcinoma of uterine cervix treated with curative radiation therapy to evaluated the prognostic factors that would affect the results of the therapy and to get the critical ideas in determining more aggressive treatment schedule. METHODS AND MATERIALS: From January 1987 to December 1988, Four hundreds and sixty patients with uterine...

PURPOSE: Patients with cervical cancer who have positive resection margins after radical hysterectomy are at increased risk for local recurrence. The results of postoperative pelvic radiotherapy for cervix cancer with positive resection margins were analyzed to evaluated the role of radiotherapy. MATERIALS AND METHODS: Between 1979 and 1992, 60 patients of cervix carcinoma were treated with postoperative radiotherapy after radical hysterectomy...

PURPOSE: The wedge filter is the most commonly used beam modifying device during radiation therapy. Recently dynamic wedge technique is available through the computer controlled asymmetric collimator, independent jaw. But dosimetric characteristics of dynamic wedge technique is not well know. Therefore we evluate dosimetric characteristics of dynamic wedge compared to conventional fixed wedge. MATERIALS AND METHODS: We evaluated dosimetric characteristics of dynamic...

PURPOSE: To evaluate the clinical implications of scallp penumbra width that comes from multileaf collimator(MLC) effect by the daily routine patient setup error. MATERIALS AND METHODS: The angles of 0degree, 15degree, 30degree, 45degree, 60degree and 75degree inclined-radiation blocked fields were generated using the both conventional cerrobend block and the MLC. Film dosimetry in the phantom were performed to measure penumbral widths...

PURPOSE: This study was performed for adequate irradating tumor area when 6 MV linear accerelator photon was used to treat the head and neck tumor. The skin surface dose and maximum build-up ragion was measured by using a spoiler which was located between skin surface and collimator. METHODS: A spoiler was made of tissue equivalent materials and the skin surface dose...