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Table of Contents | March, 2019  Vol. 37  No.1 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Appraisal of re-irradiation for the recurrent glioblastoma in the era of MGMT promotor methylation
Il Han Kim
Radiat Oncol J. 2019;37(1):1-12.   Published online March 31, 2019
Despite recent innovation in treatment techniques and subsequently improved outcomes, the majority of glioblastoma (GBL) have relapses, especially in locoregional areas. Local re-irradiation (re-RT) has been established as a feasible option for recurrent GBL of all ages with safety, tolerability, and effectiveness both in survival and quality of life regardless of fractionation schedule. To keep adverse effects under acceptable range,...
Original Articles
Clinical Investigations
National trends in radiation dose escalation for glioblastoma
Rodney E. Wegner, Stephen Abel, Zachary D. Horne, Shaakir Hasan, Vivek Verma, Tulika Ranjan, Richard W. Williamson, Stephen M. Karlovits
Radiat Oncol J. 2019;37(1):13-21.   Published online March 31, 2019

Purpose: Glioblastoma (GBM) carries a high propensity for in-field failure despite trimodality management. Past studies have failed to show outcome improvements with dose-escalation. Herein, we examined trends and outcomes associated with dose-escalation for GBM. Materials and Methods: The National Cancer Database was queried for GBM patients who underwent surgical resection and external-beam radiation with chemotherapy. Patients were excluded if doses were...
Whole brain radiotherapy using four-field box technique with tilting baseplate for parotid gland sparing
Jaehyeon Park, Ji Woon Yea
Radiat Oncol J. 2019;37(1):22-29.   Published online March 31, 2019

Purpose: The aim of this study is to evaluate the efficacy and feasibility of four-field box whole brain radiotherapy (FB-WBRT) with tilting baseplate by comparing bilateral WBRT (B-WBRT). Methods and Materials: Between March 2016 and September 2018, 20 patients with brain metastases underwent WBRT using the four-field box technique. WBRT is performed with a dose of 30 Gy in 10 fractions...
Maximum standardized uptake value at pre-treatment PET in estimating lung cancer progression after stereotactic body radiotherapy
Jisun Park, Yunseon Choi, Ki Jung Ahn, Sung Kwang Park, Heunglae Cho, Ji Young Lee
Radiat Oncol J. 2019;37(1):30-36.   Published online March 31, 2019

Purpose: This study aimed to identify the feasibility of the maximum standardized uptake value (SUVmax) on baseline 18F-fluorodeoxyglucose positron emission tomography-computed tomography (FDG PET/CT) as a predictive factor for prognosis in early stage primary lung cancer treated with stereotactic body radiotherapy (SBRT). Materials and Methods: Twenty-seven T1-3N0M0 primary lung cancer patients treated with curative SBRT between 2010 and 2018 were retrospectively...
Survival outcomes after adjuvant radiotherapy for aggressive fibromatosis depend on time frame and nuclear β-catenin
Jae Sik Kim, Hak Jae Kim, Me-Yeon Lee, Kyung Chul Moon, Seung Geun Song, Han-Soo Kim, Ilkyu Han, Il Han Kim
Radiat Oncol J. 2019;37(1):37-42.   Published online March 31, 2019

Purpose: To identify prognostic factors influencing progression-free survival (PFS) of aggressive fibromatosis (AF) after postoperative radiotherapy (PORT) and assess correlations between immunohistochemistry (IHC) features of β-catenin/smooth muscle actin (SMA) and PFS. Materials and Methods: Records of 37 patients with AF treated by PORT from 1984 to 2015 were retrospectively reviewed. Fifteen patients underwent wide excision for AF and 22 patients received...
The use of tissue fiducial markers in improving the accuracy of post-prostatectomy radiotherapy
Michael Chao, Huong Ho, Daryl Lim Joon, Yee Chan, Sandra Spencer, Michael Ng, Jason Wasiak, Nathan Lawrentschuk, Kevin McMillan, Shomik Sengupta, Alwin Tan, George Koufogiannis, Margaret Cokelek, Farshad Foroudi, Tristan-Scott Khong, Damien Bolton
Radiat Oncol J. 2019;37(1):43-50.   Published online March 31, 2019

Purpose: The aim of this retrospective study was to investigate the use of a radiopaque tissue fiducial marker (TFM) in the treatment of prostate cancer patients who undergo post-prostatectomy radiotherapy (PPRT). TFM safety, its role and benefit in quantifying the set-up uncertainties in patients undergoing PPRT image-guided radiotherapy were assessed. Materials and Methods: A total of 45 consecutive PPRT patients underwent...
Observational approach on regional lymph node in cutaneous melanomas of extremities
Bum-Sup Jang, Keun-Yong Eom, Hwan Seong Cho, Changhoon Song, In Ah Kim, Jae-Sung Kim
Radiat Oncol J. 2019;37(1):51-59.   Published online March 31, 2019

Purpose: We evaluated failure pattern and treatment outcomes of observational approach on regional lymph node (LN) in cutaneous melanoma of extremities and sought to find clinico-pathologic factors related to LN metastases. Material and Methods: We retrospectively reviewed 73 patients with cutaneous melanoma of extremities between 2005 and 2016. If preoperative 18-F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) findings were non-specific for regional...
Enhancing value of quality assurance rounds in improving radiotherapy management: a retrospective analysis from King Hussein Cancer Center in Jordan
Jamal K. Khader, Abdelatif M. Al-Mousa, Issa A. Mohamad, Ramiz A. Abuhijlih, Sondos A. Al-Khatib, Anoud Z. Alnsour, Wafa A. Asha, Shada W. Ramahi, Ali A. Hosni, Fawzi J. Abuhijla
Radiat Oncol J. 2019;37(1):60-65.   Published online March 31, 2019

Purpose: The quality assurance (QA) chart rounds are multidisciplinary meetings to review radiation therapy (RT) treatment plans. This study focus on describing the changes in RT management based on QA round reviews in a single institution. Materials and Methods: After 9 full years of implementation, a retrospective review of all patients whose charts passed through departmental QA chart rounds from 2007...
Poetry and Radiation Oncology
Loss of movement
Sophia Valesca Görgens
Radiat Oncol J. 2019;37(1):66-66.   Published online March 31, 2019
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