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Table of Contents | March, 2022  Vol. 40  No.1 Previous Issue | Next Issue | Archive
In this issue:




Review Article
Reviewing the potential role of radiation therapy in gallbladder cancer: an update
Divyesh Kumar, Nali Muni Kiran, Divya Khosla
Radiat Oncol J. 2022;40(1):1-8.   Published online January 25, 2022
Gallbladder cancer is a highly malignant disease with a poor prognosis. It is the most common cancer of the biliary tract pathway. Although surgery remains the treatment of choice for early-stage disease, majority of the patients presents in locally advanced, unresectable and metastatic stage of the disease. Radiotherapy and chemotherapy thus form an integral part of management for these locally...
Original Articles
Clinical Investigation
Limited field adaptive radiotherapy for glioblastoma: changes in target volume and organ at risk doses
Öznur Şenkesen, Evrim Tezcanlı, Mehmet Ufuk Abacıoğlu, Zeynep Özen, Derya Çöne, Halil Küçücük, Evren Ozan Göksel, Alptekin Arifoğlu, Meriç Şengöz
Radiat Oncol J. 2022;40(1):9-19.   Published online March 28, 2022
Objective: This study aimed to investigate the tumor volume changes occurring during limited-field radiotherapy (RT) for glioblastoma patients and whether a volume-adapted boost planning approach provided any benefit on tumor coverage and normal tissue sparing. Meterials and Methods: Twenty-four patients underwent simulation with magnetic resonance (MR) and computed tomography (CT) scans prior to RT (MR_initial, CT_initial) and boost treatment (MR_adapt,...
PIVKA-II as a surrogate marker for prognosis in patients with localized hepatocellular carcinoma receiving stereotactic body radiotherapy
Ick Joon Cho, Jae-Uk Jeong, Taek-Keun Nam, Young-Eun Joo, Sung-Bum Cho, Yong-Hyub Kim, Ju-Young Song, Mee Sun Yoon, Sung-Ja Ahn, Woong-Ki Chung
Radiat Oncol J. 2022;40(1):20-28.   Published online March 25, 2022

Purpose: This study aimed to determine the correlation between protein induced by vitamin K absence or antagonist-II (PIVKA-II) and stereotactic body radiotherapy (SBRT) in patients with hepatocellular carcinoma (HCC). Materials and Methods: Sixty-one patients received SBRT between 2015 and 2020 with a median dose of 48 Gy (range, 39 to 60 Gy) with a median of 4 fractions. Changes in...
Trends in the use of radiation for meningioma across the United States
Hirsch Matani, Stephen Abel, Alexander Yu, Stephen M. Karlovits, Rodney E. Wegner
Radiat Oncol J. 2022;40(1):29-36.   Published online March 15, 2022

Purpose: Meningiomas are tumors originating from arachnoid cap cells on the surface of the brain or spinal cord. Treatment differs by grade but can consist of observation, surgery, radiation therapy or both. We utilized the National Cancer Database (NCDB) to compare trends in the use stereotactic radiosurgery (SRS) and external beam radiation therapy (EBRT) in the management of meningioma. Materials...
Optimal positive lymph node ratio showing the benefit of postoperative radiotherapy in pathologic N2 non-small cell lung cancer: an exploratory study using the Surveillance, Epidemiology, and End Results data
Shiho Lee, O Kyu Noh
Radiat Oncol J. 2022;40(1):37-44.   Published online March 22, 2022

Purpose: This study aimed to identify the clinical parameters having the beneficial effect of postoperative radiotherapy (PORT) in pathologic N2 (pN2) non-small cell lung cancer (NSCLC) using the Surveillance, Epidemiology, and End Results (SEER) data. Materials and methods: Among non-metastatic NSCLC patients in the SEER data, we included patients who diagnosed after 2002, who confirmed as pN2 after lobectomy or...
Long-term outcomes of low-dose radiotherapy in Kasabach-Merritt syndrome
Dowook Kim, Jung Yoon Choi, Kyung Taek Hong, Hyoung Jin Kang, Il Han Kim, Joo Ho Lee
Radiat Oncol J. 2022;40(1):45-52.   Published online March 22, 2022

Purpose: Reports on results of radiation therapy (RT) for Kasabach-Merritt syndrome (KMS) are limited. We performed a retrospective study to evaluate the response rates and late complications and to determine the adequate RT dose for patients with KMS patients. Materials and Methods: We studied 11 patients who received RT between October 1988 and September 2008 for KMS refractory to pharmacologic therapy....
Biology contribution
Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy
Yeeun Kim, Changhoon Choi, Jee Hyun Park, Won-Gyun Ahn, Sung-Won Shin, Shin-Yeong Kim, Jae Myoung Noh
Radiat Oncol J. 2022;40(1):53-65.   Published online February 23, 2022

Purpose: This study aims to investigate the effect of splenectomy on radiation-mediated growth inhibition and immune modulation in lung cancer xenograft models. Materials and Methods: Human non-small cell lung cancer H1299 cells and murine Lewis lung carcinoma LL/2-luc cells were injected into the right hind leg of BALB/c-nude mice and C57BL/6 mice, respectively. Splenectomy or sham operation was performed prior...
PA1 cells containing a truncated DNA polymerase β protein are more sensitive to gamma radiation
Anutosh Patra, Anish Nag, Anindita Chakraborty, Nandan Bhattacharyya
Radiat Oncol J. 2022;40(1):66-78.   Published online March 29, 2022

Purpose: DNA polymerase β (Polβ) acts in the base excision repair (BER) pathway. Mutations in DNA polymerase β (Polβ) are associated with different cancers. A variant of Polβ with a 97 amino acid deletion (PolβΔ), in heterozygous conditions with wild-type Polβ, was identified in sporadic ovarian tumor samples. This study aims to evaluate the gamma radiation sensitivity of PolβΔ for...
Case Report
Radiation therapy in chronic hidradenitis suppurativa: case report
Pitchaya Sakyanun, Thirada Vongvanichvathana, Prasert Lertsanguansinchai
Radiat Oncol J. 2022;40(1):79-85.   Published online March 3, 2022
A 26-year-old female presented recurrent painful, carbuncles at both axillae for 10 years. It caused offensive odor and scar. Tissue diagnosis was chronic hidradenitis suppurativa. She was treated using antibiotics followed by multiple excisions with drainage but showed no improvement. Isotretinoin provided no benefit. She was socially isolated and experienced lower quality of life. Consequently, she was sent for radiation...
Letter to the Editor
Comment on “Abscopal effect in the radio and immunotherapy”
François Fabi
Radiat Oncol J. 2022;40(1):86-87.   Published online March 22, 2022
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