Purpose: The systemic immune-inflammation index (SII) is a prognostic biomarker in various solid tumors. However, the prognostic role of SII in thymic epithelial tumors (TETs) receiving adjuvant radiotherapy (RT) has not yet been explored. This study aims to assess the prognosti...
Purpose: This study investigates patterns of postmastectomy radiation therapy (PMRT) use in patients with pT1–2N1 breast cancer treated with mastectomy in Korea over 2 decades.
Materials and Methods: Data from 700 patients treated at 16 institutions across three decades (1990,...
Purpose: Lymphocytopenia is a known side effect of radiation exposure to the bone marrow. However, the hematological impact of irradiating the bowel bag—a highly vascularized region containing numerous mesenteric lymph nodes—remains poorly understood. This study aimed to exam...
Purpose: Palliative thoracic radiotherapy plays a crucial role in the management of patients with non–small cell lung cancer (NSCLC). Conventional dose-fractionation schemes often yield modest and short-lived tumor responses. This study aims to evaluate the efficacy and safety ...
Purpose: This study aimed to develop prediction models for severe oral mucositis (OM) (grade ≥ 3) from head and neck cancer (HNC) radiotherapy (RT) using machine learning (ML) techniques and different types of features, including clinical, dose-volume metric, and radiomic featu...
Purpose: This study aims to figure out prognostic factors affecting treatment outcomes for early-stage endometrial cancer patients undergoing adjuvant vaginal brachytherapy (VBT) and to develop a histopathological risk stratification model.
Materials and Methods: We retrospecti...
Ornithine transcarbamylase (OTC) deficiency is a rare urea cycle disorder that impairs ammonia detoxification, increasing the risk of hyperammonemic crises under metabolic stress. While chemotherapy-related risks have been reported, data on the safety of ionizing radiation thera...
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Alper Kahvecioglu, Mervenur Bay, Pervin Hurmuz, Mustafa Cengiz
Radiat Oncol J. 2025;43(4):165-171. Published online August 27, 2025
Purpose: The systemic immune-inflammation index (SII) is a prognostic biomarker in various solid tumors. However, the prognostic role of SII in thymic epithelial tumors (TETs) receiving adjuvant radiotherapy (RT) has not yet been explored. This study aims to assess the prognostic role of pre-RT SII in TET patients undergoing adjuvant RT.
Materials and Methods: A retrospective analysis was conducted on 37...
Mi Sun Kim, Seung Do Ahn, Yong Bae Kim, Won Park, Shin-Hyung Park, Ik Jae Lee, Byung-Ock Choi, Juri Kim, Sung Ja Ahn, Won Sup Yoon, Jin-hee Kim, Jong Hoon Lee, Donghyun Kim, Hye Li Park, Yeon-Joo Kim, Sun Young Lee, Kyung Ran Park, Division for Breast Cancer, Korean Radiation Oncology Group
Radiat Oncol J. 2025;43(4):172-180. Published online December 8, 2025
Purpose: This study investigates patterns of postmastectomy radiation therapy (PMRT) use in patients with pT1–2N1 breast cancer treated with mastectomy in Korea over 2 decades.
Materials and Methods: Data from 700 patients treated at 16 institutions across three decades (1990, 2000, and 2010) were retrospectively reviewed.
Results: Overall, 10.0% of patients received PMRT, with utilization rates of 7.4%, 8.8%, and 11.1% in...
Min Kyun Ko, Kyu Hye Choi, Wonmo Sung, Ji Hyun Hong, Seok Hyun Son, Young-nam Kang, Byung-Ock Choi, Yeon-Sil Kim, HongSeok Jang
Radiat Oncol J. 2025;43(4):181-187. Published online December 8, 2025
Purpose: Lymphocytopenia is a known side effect of radiation exposure to the bone marrow. However, the hematological impact of irradiating the bowel bag—a highly vascularized region containing numerous mesenteric lymph nodes—remains poorly understood. This study aimed to examine whether radiation to the bowel bag leads to a decrease in absolute lymphocyte count (ALC) during pelvic radiotherapy.
Materials and Methods: We retrospectively...
James C. H. Chow, Jeffrey C. F. Lui, Chris K. C. Tong, Anthony H. P. Tam, Jeffrey C. H. Chan, Jeannie Y. K. Chik, Gavin T. C. Cheung, Ka Man Cheung, Luke T. Y. Lee, Kam Hung Wong, Kwok Hung Au
Radiat Oncol J. 2025;43(4):188-194. Published online October 27, 2025
Purpose: Palliative thoracic radiotherapy plays a crucial role in the management of patients with non–small cell lung cancer (NSCLC). Conventional dose-fractionation schemes often yield modest and short-lived tumor responses. This study aims to evaluate the efficacy and safety of a high-dose hypofractionated radiotherapy regimen of 40 Gy in 10 daily fractions in NSCLC.
Materials and Methods: Consecutive NSCLC patients who...
Radiat Oncol J. 2025;43(4):195-205. Published online December 15, 2025
Purpose: This study aimed to develop prediction models for severe oral mucositis (OM) (grade ≥ 3) from head and neck cancer (HNC) radiotherapy (RT) using machine learning (ML) techniques and different types of features, including clinical, dose-volume metric, and radiomic features.
Materials and Methods: Retrospective data of 148 HNC RT patients were collected and randomly divided into 80% training and 20%...
Hae Sol Lim, Won Park, Won Kyung Cho, Jeong-Won Lee, Chel Hun Choi, Tae-Joong Kim, Yoo-Young Lee
Radiat Oncol J. 2025;43(4):206-213. Published online December 5, 2025
Purpose: This study aims to figure out prognostic factors affecting treatment outcomes for early-stage endometrial cancer patients undergoing adjuvant vaginal brachytherapy (VBT) and to develop a histopathological risk stratification model.
Materials and Methods: We retrospectively reviewed International Federation of Gynecology and Obstetrics stage I endometrioid endometrial cancer patients who underwent primary surgery followed by VBT from January 2010 to December 2022....
Iris Kang, Justin Park, Christine Yang, Aster Kim, Mary Tang, Kaye Lu, Azadeh Carr, Stephen F. Sener, Rachel McGowan, Shoji Yano, Stella K. Yoo
Radiat Oncol J. 2025;43(4):214-219. Published online December 19, 2025
Ornithine transcarbamylase (OTC) deficiency is a rare urea cycle disorder that impairs ammonia detoxification, increasing the risk of hyperammonemic crises under metabolic stress. While chemotherapy-related risks have been reported, data on the safety of ionizing radiation therapy (RT) in this population are limited. This case describes a 30-year-old woman with late-onset OTC deficiency diagnosed with right-sided ductal carcinoma in situ....
, Mervenur Bay
, Jeffrey C. F. Lui
, Sasikarn Chamchod
, Justin Park
