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J Korean Soc Ther Radiol > Volume 8(2); 1990 > Article
Journal of the Korean Society for Therapeutic Radiology 1990;8(2): 183-188.
Nasopharyngeal Cancer in Patients Under Thirty Years of Age
Ki Jung Ahn, Eun Ji Chung, Hyung Sik Lee, Sun Rock Moon, Jin Sil Seong, Gwi Eon Kim, Chang Ok Suh, John J Kyu Loh
Department of Radiation Oncology, Yousei University College of Medicine, Seoul, Korea.
ABSTRACT
Between January 1971 and December 1987, 113 patients with nasopharyngeal cancer (NPC) were treated by radiation therapy with or without chemotherapy in the department of Radiation Oncology, Yonsei University Hospital. There were 19 patients under thirty years of age. The histology was undifferentiated carcinoma in 68% of the younger patients as compared to 47% of the older patients. Sex, stage, initial symptoms and treatment modalities differed little from those of older patients. In younger patients, the initial complete response rate was 79% as compared to older patients with 54%, distant metastases were more common and the overall five year survival rate was not significantly different between the two age groups (33.7% for the young vs. 37.4% for the old). The five year survival rates for stage III and IV were 60.0% and 24.5%, respectively. Histologic subtype was not correlated with survival. The best survival was found only in patients who obtained a complete clearance of disease after radiation therapy. Adjuvant chemotherapy is suggested as an important target for further study.
Key Words: Nasopharyngeal carcinoma, Radiation therapy, Survival
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