Acute Response to Co-60 Total Body Irradiation (TBI) With 600 cgy at 3 Different Does Rates in the Mice

Kang,  Cheol Hoon; Kum,  Sung Kyu; Shin,  Sei One; Kim,  Myung Se

J Korean Soc Ther Radiol > Volume 8(2); 1990 > Article

Original Article

Journal of the Korean Society for Therapeutic Radiology 1990;8(2): 151-154.

Acute Response to Co-60 Total Body Irradiation (TBI) With 600 cgy at 3 Different Does Rates in the Mice

Cheol Hoon Kang, Sung Kyu Kum, Sei One Shin, Myung Se Kim

Department of Therapeutic Radiology, College of Medicine, Yeungnam University, Taegu, Korea.

ABSTRACT

The acute effects of variable dos rates to total body irradiation (TBI) were investigated with 600 cgy of single exposure in the mice as a preclinical model. Total 80 mice (ICR) were used. Twenty of which served as controls, receiving no irradiation. All irradiated mice showed a universal decline in their weight and white blood cell count. The degree of weight loss and leukopenia were similar at 3 different dos rate but slightly prominent with 15 cgy/minute group. The degree of recovery among the groups showed no dose rate dependence. Our results suggest that TBI with 15 cgy/minute may be applicable for clinical therapy with careful evaluation of patient's condition.

Key Words: Total body irradiation, Dose rate, Acute effects