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J Korean Soc Ther Radiol > Volume 8(1); 1990 > Article
Journal of the Korean Society for Therapeutic Radiology 1990;8(1): 65-73.
Treatment Results and Prognostic Factors in the Management of Locoregional Recurrent Breast Carcinoma
Sun Rock Moon, Hyung Sik Lee, Gwi Eon Kim, Ki Jung Ahn, Chang Ok Suh, John J Kyu Loh, Jin Sik Min, Kyung Sik Lee, Byung Soo Kim, Jae Kyung Noh, Eun Hee Koh
1Department of Radiation Oncology, Yonsei University College of Medicine, Yonsei Cancer Center, Korea.
2Department of Surgery, Yonsei University College of Medicine, Yonsei Cancer Center, Korea.
Between January, 1974 and December 1986, fifty eight patients with locoregional recurrent breast carcinoma who did not have evidence of distant metastasis after initial treatment of surgery with or without adjuvant chemotherapy were treated with radiation therapy. Among them, five patients were excluded from this study because of incomplete record or incomplete treatment. The 5-year overall survival and disease free survival from the time of locoregional recurrence was 27% and 15% respectively. In univariate analysis of prognostic variables, the clinical stage at initial diagnosis, recur duration, number of recurrence sites, size of recurrences, response to the treatment, remission duration were all found to have no significant effect on survival or disease free survial. On the other hand, menopausal status at initial diagnosis, number of positive node at initial surgery, whether or not the use of adjuvant chemotherapy after initial mastectomy had definite prognositc significance. In multivariate analysis of prognostic variables, remission duration, menopausal status at diagnosis, number of axillary node at mastectomy had definite prognostic significance. On the other hand, remission duration more than 12 months, premenopaus at initial mastectomy, less than four positive axillary lymph nodes at mastectomy predicted a good prognosis.
Key Words: Radiotherapy, Local recerrent breast carcinoma, Prognostic factor
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