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J Korean Soc Ther Radiol > Volume 8(1); 1990 > Article
Journal of the Korean Society for Therapeutic Radiology 1990;8(1): 1-6.
Improving Oxygenation in the Murine Tumors by a perfluorochemical Emulsion (Fluosl-DA 20%)
Intae Lee, Gwi E Kim, Chang W Song
1Department of Therapeutic Radiology, University of Minnesota Medical School, Harvard Street at East River Road.Box 494 UMHC Minneapolis, MN 55455, U.S.A.
2Department of Radiation Oncology, Yonsei University Medical College, Yonsei Cancer Center, Seoul, Korea.
In the present study, a perfluorochemical emulsion (Fluosol-DA 20%) did not alter Do and and Dq values on cell survival curve, indicating that the lack of a direct effect of Fluosol-DA 20% on cellular radiosensitivity in vitro. The effect of Fluosol-DA 20% injection in combination with carbogen breathing was determined on the hupoxic cell fraction in SCK tumors. The hypoxic cell fraction in control SCK tumors was 0.39. This value decreased to 0.05 when the mice were i.v. injected with 12 ml/kg of Fluosol-DA 20% in a carbogen atomosphere. The measured mean and median PO2 values with a microelectorde in the control tumors was 9 mmHg and 4 mmHg, respectively. The treatment of the SCK tumors in the host mice with injected Fluosol-DA 20% in combination with carbogen breathing increased the mean and median PO2 values to 67 mmHg and 62 mmHg, respectively. Using carbogen breathing alone caused a moderate increase of tumor PO2. But Fluosol-DA 20% injection alone caused little change PO2 in the tumor. It was concluded that the combination of Fluosol-DA injection and carbogen breathing is an effective means to improve oxygenation of tumors.
Key Words: A Perfluorochemical Emulsion, Fluosol-DA 20%, Intratumor PO2, Hypoxic cell fraction, Carbogen breathing, SCK tumors
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