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J Korean Soc Ther Radiol > Volume 6(2); 1988 > Article
Journal of the Korean Society for Therapeutic Radiology 1988;6(2): 247-252.
Total Body Irradiation in Leukemia: Preliminary Report
Hong Seok Jang, Su Mi Chung, Ihl Bohng Choi, Choon Yul Kim, Yong Whee Bahk, Choon Choo Kim, Dong Jip Kim, Jae Soo Lee
1Department of Radiology, Catholic University Medical College, Seoul, Korea.
2Department of Internal Medicine, Catholic University Medical College, Seoul, Korea.
3Department of Radiation Oncology, Yonsei Univeristy College of Medicine, Seoul, Korean.
ABSTRACT
Total body irradiation has been applied to treat acute leukemia and chronic granulocytic leukemia. 20 patients with acute leukemia or chronic granulocytic leukemia were treated with total body irradiation using 6 MV linear accelerator before bone marrow transplantation at the Division of Therapeutic Radiology, department of Radiology, St. Mary's Hospital, catholic University Medical College from August 1987 to September 1988. Among 20 patients, 8 patients received 6 fractions of 200 cgy (total 1200 cgy), 10 patients received a single 850 cgy radiation, 1 patient received 4 fractions totaling 850 cgy (200, 200, 200, 250), and 1 patient received 1100 cgy in 2 fractions (850, 250). 17 patients received allogenic grafts, 2 patients received autologous grafts, and only one patients received one locus mismatched graft. 13 patients are still alive and 7 patients died. The complications induced by total body irradiation were nausea and vomiting, diarrhea, skin eruption, mucositis, and pneumonitis.
Key Words: Total body irradiation, Leukemia, Bone marrow transplantation
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