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J Korean Soc Ther Radiol > Volume 6(2); 1988 > Article
Journal of the Korean Society for Therapeutic Radiology 1988;6(2): 151-154.
A Study on the Radiation Tumor Control Microscopic Tumors of the C3Hf/Sed Mouse Spontaneous Fibrosarcoma
Sung Whan Ha, Herman D Suit
1Edwin L. Steel Laboratory of Radiation Biology, U.S.A
2Department of Radiation Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
ABSTRACT
To answer the question whether last clonogenic cell should be eradicated for the tumor to be controlled, radiation tumor control study was performed using microscopic tumors of variable sizes ranging from 101 to 105 tumor cells. TCD50's estimated from experimental data were 14.8, 27.1, 42.4, 49.9 and 65.5 gy for 10(1), 10(2), 10(3), 10(4) and 10(5) tumor cells, respectively. Theoretical calculations, assuming that all the clonogenic cells should be inactivated, were 15.65, 28.50, 40.97, 53.41 and 65.85 gy. From this well matched data, it can be concluded that all the clonogenic cells should be eradicated for tumor control, at least in this tumor model.
Key Words: Clonogenic cell, Microscopic, Fibrosacoma, Mouse
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