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J Korean Soc Ther Radiol > Volume 5(2); 1987 > Article
Journal of the Korean Society for Therapeutic Radiology 1987;5(2): 75-82.
The RBE of Fractionated Fast Neutron on Walker 256 Carcinosarcoma with KCCH-Cyclotron
Seong Yul Yoo, Kyoung Hwan Koh, Chul Koo Cho, Charn Il Park, Wee Saing Kang
1Department of Therapeutic Radiology, Korea Cancer Center Hospital, KAERI, Seoul, Korea.
2Department of Therapeutic Radiology, College of Medicine, Seoul National University, Korea.
ABSTRACT
For evaluation of biological effect of p+(50.5 MeV) Be neutron beam produced by Korea Cancer Center Hospital(KCCH) cyclotron the RBE had been measured in experimental tumor Walker 256 carcinosarcoma as well as normal tissue, mouse intestine and bone marrow, in single and fractionated irradiation. As pilot study, the RBE had been measured for the mouse jejunal crypt cells in single whole body irradiation of which the result was 2.8. The obtained RBE values of TCD 50 of Walker 256 tumor, bone marrow and intestine in single irraiation were 1.9, 1.9 and 1.5 respectively. In fractionated irradiation, the RBE value of tumor Walker 256 was decreased as increasing of fraction number and increased as increaing of fraction size.
Key Words: RBE, Fast neutron, Walker 256 carcinosarcoma, KCCH-cyclotron
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