Radiation Effect on Body Weight and Hematological Changes of Hybrid Mice by Conventional Fraction, Large Abdominal FieldIrradiation

Lee,  Sung Heon; Shin,  Sei One; Kim,  Myung Se

J Korean Soc Ther Radiol > Volume 3(2); 1985 > Article

Original Article

Journal of the Korean Society for Therapeutic Radiology 1985;3(2): 153-158.

Radiation Effect on Body Weight and Hematological Changes of Hybrid Mice by Conventional Fraction, Large Abdominal FieldIrradiation

Sung Heon Lee, Sei One Shin, Myung Se Kim

Department of Therapeutic Radiology, College of Medicine, Yeung Nam University, Korea.

ABSTRACT

Radiation effect on mammals, especially on hematologic changes, has been studied since discovery of x-ay. Various experimental animals were tried for radiobiological studies. 72 hybrid mice with conventional ffaction (5X/week), large abdominal field (2 x3cm, from symphysis pubic to xyphoid process) were used. Body weight was declined gradually by increasing irradiation doses, nadir was about 29.7% in male ; 30.4% in female at 6000 rad irradiation group. Hemoglobin value was nearly normal throughout entire treatment. Significant dropping of WBC count was noted to 40-0% of pretreatment values by only 1000 rad irradiation. Change of differential count was interesting; lymphocyte proportion showed gradual reduction, instead of gradual increasing of segmented neutrophil. Those proportion were reversed after 6000 rad irradiation. Urinary protein tests showed + - +++, showing no correlation with dosage. Application. of our study in clinical combination therapy (radiation + chemotherapy) was discussed.

Key Words: Radiation effect, Hematologic changes, Large abdominal field