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J Korean Soc Ther Radiol Oncol > Volume 28(2); 2010 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2010;28(2): 79-84. doi: https://doi.org/10.3857/jkstro.2010.28.2.79
The Results of Intraoperative Radiotherapy for Stomach Cancer
Ji Hoon Choi, Min Kyu Kang, Myung Se Kim, Sung Kyu Kim, Sang Mo Yun, Sung Hoon Kim
Department of Radiation Oncology, Yeungnam University College of Medicine, Daegu, Korea. mkkang@ynu.ac.kr
We retrospectively analyzed the long-term results of radical surgery and intraoperative radiation therapy (IORT) in patients with stomach cancer.
From 1988 to 1994, 51 patients were treated with curative surgery and IORT. Postoperative external beam radiotherapy (EBRT) was administered to 30 patients, while adjuvant chemotherapy was administered to 35 patients. A dose of 15 Gy was irradiated with a 9 MeV electron beam as the IORT and a median dose of EBRT was 43.2 Gy (range, 7.2 to 45 Gy). The follow-up period ranged from 1~254 months, with a median follow-up period of 64 months.
The median age of all the patients was 58 years (range, 30 to 71 years). The distribution of pathologic stage (American Joint Committee on Cancer [AJCC] 2002 tumor-note-metastasis [TNM]) was as follows: 13 stage I (25.5%), 10 stage II (19.6%), 25 stage III (49.0%), and 3 stage IV (5.9%). Distant metastases occurred in 11 patients (10 in the peritoneum and 1 in bone), including one patient with concurrent local recurrence (anastomosis site). The 5-year locoregional control, disease free survival and overall survival rates were 94.7%, 66.5%, and 51.7%, respectively. For the multivariate analysis, age, TNM stage, and EBRT were significant prognostic factors for overall survival, and only TNM stage for disease free survival.
We could have achieved a high loco-regional control rate in patients with locally advanced stomach cancer by adding IORT to radical surgery. However, the benefit of IORT on survival remains to be elucidated.
Key Words: Stomach cancer, Surgery, Intraoperative radiotherapy
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