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J Korean Soc Ther Radiol Oncol > Volume 26(4); 2008 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2008;26(4): 222-228. doi: https://doi.org/10.3857/jkstro.2008.26.4.222
Perineal Skin Toxicity according to Irradiation Technique in Radiotherapy of Anal Cancer
Sei Hwan You, Jinsil Seong, Woong Sub Koom
Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University Health System, Seoul, Korea. jsseong@yuhs.ac
Various treatment techniques have been attempted for the radiotherapy of anal cancer because of acute side effects such as perineal skin reactions. This study was performed to investigate an optimal radiotherapy technique in anal cancer.
The study subjects included 35 patients who underwent definitive concurrent chemoradiotherapy for anal cancer in Yonsei Cancer Center between 1990 and 2007. The patients' clinical data, including irradiation technique, were reviewed retrospectively. The primary lesion, regional lymph nodes, and both inguinal lymph nodes were irradiated by 41.4~45 Gy with a conventional schedule, followed by a boost does to the primary lesion or metastatic lymph nodes. The radiotherapy technique was classified into four categories according to the irradiation field and number of portals. In turn, acute skin reactions associated with the treatment interruption period were investigated according to each of the four techniques.
28 patients (80.0%) had grade 2 radiation dermatitis or greater, whereas 10 patients (28.6%) had grade 3 radiation dermatitis or greater during radiotherapy. Radiation dermatitis and the treatment interruption period were relatively lower in patients belonging to the posterior-right-left 3 x-ray field with inguinal electron boost and in patients belonging to electron thunderbird techniques. The interruption periods were 8.2+/-10.2 and 5.7+/-7.7 for the two technique groups, respectively. Twenty-seven patients (77.1%) went into complete remission at 1 month after radiotherapy and the overall 5 year survival rates were 67.7%.
Field size and beam arrangement can affect patients' compliance in anal cancer radiotherapy, whereas a small x-ray field for the perineum seems to be helpful by decreasing severe radiation dermatitis.
Key Words: Anal cancer, Radiotherapy, Skin reaction
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