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J Korean Soc Ther Radiol Oncol > Volume 25(4); 2007 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2007;25(4): 242-248.
The Effect of Recombinant Human Epidermal Growth Factor on Cisplatin and Radiotherapy Induced Oral Mucositis in Mice
Jae Boem Na, Hye Jung Kim, Gyu Young Chai, Sang Wook Lee, Kang Kyoo Lee, Ki Churl Chang, Byung Ock Choi, Hong Seok Jang, Bea Keon Jeong, Ki Mun Kang
1Department of Diagnostic Radiology, Gyeongsang National University School of Medicine, Jinju, Korea.
2Department of Pharmacology, Gyeongsang National University School of Medicine, Jinju, Korea. jsk92@gnu.ac.kr
3Department of Radiation Oncology, Gyeongsang National University School of Medicine, Jinju, Korea.
4Department of Radiation Oncology, University of Ulsan College of Medicine, Seoul, Korea.
5Department of Radiation Oncology, Wonkwang University College of Medicine, Iksan, Korea.
6Department of Radiation Oncology, The Catholic University of Korea College of Medicine, Seoul, Korea.
To study the effect of recombinant human epidermal growth factor (rhEGF) on oral mucositis induced by cisplatin and radiotherapy in a mouse model.
Twenty-four ICR mice were divided into three groups? the normal control group, the no rhEGF group (treatment with cisplatin and radiation) and the rhEGF group (treatment with cisplatin, radiation and rhEGF). A model of mucositis induced by cisplatin and radiotherapy was established by injecting mice with cisplatin (10 mg/kg) on day 1 and with radiation exposure (5 Gy/day) to the head and neck on days 1~5. rhEGF was administered subcutaneously on days -1 to 0 (1 mg/kg/day) and on days 3 to 5 (1 mg/kg/day). Evaluation included body weight, oral intake, and histology.
For the comparison of the change of body weight between the rhEGF group and the no rhEGF group, a statistically significant difference was observed in the rhEGF group for the 5 days after day 3 of the experiment. The rhEGF group and no rhEGF group had reduced food intake until day 5 of the experiment, and then the mice demonstrated increased food intake after day 13 of the of experiment. When the histological examination was conducted on day 7 after treatment with cisplatin and radiation, the rhEGF group showed a focal cellular reaction in the epidermal layer of the mucosa, while the no rhEGF group did not show inflammation of the oral mucosa.
These findings suggest that rhEGF has a potential to reduce the oral mucositis burden in mice after treatment with cisplatin and radiation. The optimal dose, number and timing of the administration of rhEGF require further investigation.
Key Words: Oral mucositis, Cisplatin, Irradiation, Recombinant human epidermal growth factor, Mice
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