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J Korean Soc Ther Radiol Oncol > Volume 24(1); 2006 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2006;24(1): 67-76.
Effects of Recombinant Human Epidermal Growth Factor (rhEGF) on Experimental Radiation-Induced Oral Mucositis in Rats
Kwonil Jung, Sunhee Kim, Soo Young Moon, Yeon Wha Kim, Joon Pio Hong, Hyun Sook Kim, Sang wook Lee
1Department of Toxicology, Daewoong Pharmaceutical Co., LTD., Yongin, Korea.
2Department of Pharmacology, Daewoong Pharmaceutical Co., LTD., Yongin, Korea.
3Protein Drug Development, Institute of Bioscience and Biotechnology, Daewoong Pharmaceutical Co., LTD., Yongin, Korea.
4Department of Plastic Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
5Department of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. lsw@amc.seoul.kr
6Department of Radiology, Gyeongsang National University College of Medicine, Jinju, Korea.
ABSTRACT
PURPOSE:
Oral mucositis is a common toxicity of radiation or chemotherapy, which is used a treatment for head and neck cancer. We investigated effects of recombinant human epidermal growth factor (rhEGF) on radiation-induced oral mucositis in rat model.
MATERIALS AND METHODS:
Spraque-Dawley rats (7 per group) exposed to a single dose of 25 Gy (day 0) on their head, except for one group, were randomly divided into un-treated, vehicle-treated, and two rhEGF- treated groups. Rats were topically applied with rhEGF (15 or 30 microgram/oral cavity/day) or vehicle to their oral mucosa. Survival rate of rats, weight changes, and food intakes were examined from day 0 to 18 after radiation. Histology study was performed from oral mucosa of rats at day 7 and 18 after radiation.
RESULTS:
rhEGF-treated groups (15 or 30 microgram/day) showed all survival rate 33%, whereas un-treated and vehicle-treated groups showed all survival rate 0% at the end of experiment. rhEGF-treated groups statistically had less weight loss compared to vehicle-treated group from day 2 to 7 after radiation. Food intake of rats with rhEGF treatment turned to increase at day 14 after radiation. At 7 day after radiation, un-treated and vehicle-treated groups showed severe pseudomembraneous or ulcerative oral mucositis. On the other hand, rhEGF-treated groups had no more than cellular swelling and degeneration of epidermal cells in oral mucosa of rats.
CONCLUSION:
These results suggest that rhEGF has significantly positive effects on radiation-induced oral mucositis in rats. rhEGF display a therapeutic potential on a clinical level.
Key Words: Oral mucositis, Radiation, Epidermal growth factor, Rat model
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