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J Korean Soc Ther Radiol Oncol > Volume 23(3); 2005 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2005;23(3): 131-136.
Postoperative Radiotherapy for Parotid Gland Malignancy
Keun Yong Eom, Hong Gyun Wu, Jae Sung Kim, Charn Il Park, In Ah Kim, Kwang Hyun Kim, Chae Seo Lee
1Department of Radiation Oncology, Seoul National University College of Medicine. wuhg@snu.ac.kr
2Department of Otorhinolarynogology and Head & Neck Surgery, Seoul National University College of Medicine.
3Institute of Radiation Medicine, Medical Research Center.
4Seoul National University Cancer Research Institute, Seoul National University College of Medicine.
5Department of Radiation Oncology, Bundang Seoul National University Hospital.
The aim of this study was to evaluate the clinical results of postoperative radiotherapy for parotid gland malignancy, and determine prognostic factors for locoregional control and survival.
Between 1980 and 2002, 130 patients with parotid malignancy were registered in the database of the Department of Radiation Oncology, Seoul National University Hospital. The subjects of this analysis were the 72 of these 130 patients who underwent postoperative irradiation. There were 42 males and 30 females, with a median age of 46.5 years. The most common histological type was a mucoepidermoid carcinoma. There were 6, 23, 23 and 20 patients in Stages I, II, III and IV, respectively. The median dose to the tumor bed was 60 Gy, with a median fraction size of 1.8 Gy.
The overall 5 and 10 year survival rates were 85 and 76%, respectively. The five-year locoregional control rate was 85%, which reached a plateau phase after 6 years. Sex and histological type were found to be statistically significant for overall survival from a multivariate analysis. No other factors, including age, facial nerve palsy and stage, were related to overall survival. For locoregional control, nodal involvement and positive resection margin were associated with poor local control. Histological type, tumor size, perineural invasion and type of surgery were not significant for locoregional control.
A high survival rate of parotid gland malignancies, with surgery and postoperative radiotherapy, was confirmed. Sex and histological type were significant prognostic factors for overall survival. Nodal involvement and a positive resection margin were associated with poor locoregional control.
Key Words: Parotid gland malignancy, Postoperative radiotherapy, Prognostic factors
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