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J Korean Soc Ther Radiol Oncol > Volume 21(2); 2003 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2003;21(2): 158-166.
Conceptual Source Design and Dosimetric Feasibility Study for Intravascular Treatment: A Proposal for Intensity Modulated Brachytherapy
Siyong Kim, Eunyoung Han, Jatinder R Palta, Sung W Ha
1Department of Radiation Oncology, University of Florida, USA.
2Department of Radiological and Nuclear Engineering, University of Florida, USA.
3Department of Therapeutic Radiology, Seoul National University College of Medicine, Seoul, Korea. swha@snu.ac.kr
To propose a conceptual design of a novel source for intensity modulated brachytherapy.
The source design incorporates both radioactive and shielding materials (stainless steel or tungsten), to provide an asymmetric dose intensity in the azimuthal direction. The intensity modulated intravascular brachytherapy was performed by combining a series of dwell positions and times, distributed along the azimuthal coordinates. Two simple designs for the beta-emitting sources, with similar physical dimensions to a 90Sr/Y Novoste Beat-Cath source, were considered in the dosimetric feasibility study. In the first design, the radioactive and materials each occupy half of the cylinder and in the second, the radioactive material occupies only a quater of the cylinder. The radial and azimuthal dose distributions around each source were calculated using the MCNP Monte Carlo code.
The preliminary hypothetical simulation and optimization results demonstrated the 87% difference between the maximum and minimum doses to the lumen wall, due to off-centering of the radiation source, could be reduced to less than 7% by optimizing the azimuthal dwell positions and times of the partially shielded intravascular brachytherapy sources.
The novel brachytherapy source design, and conceptual source delivery system, proposed in this study show promising dosimetric characteristics for the realization of intensity modulated brachytherapy in intravascular treatment. Further development of this concept will center on building a delivery system that can precisely control the angular motion of a radiation source in a small-diameter catheter.
Key Words: Intensity modulation, Intravascular brachytherapy, MCNP
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