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J Korean Soc Ther Radiol Oncol > Volume 20(2); 2002 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2002;20(2): 123-129.
Preliminary Results of 3-Dimensional Conformal Radiotherapy for Primary Unresectable Hepatocellular Carcinoma
Ki Chang Keum, Hee Chul Park, Jin Sil Seong, Sei Kyoung Chang, Kwang Hyub Han, Chae Yoon Chon, Young Myoung Moon, Gwi Eon Kim, Chang Ok Suh
1Department of Radiation Oncology, Yonsei University College of Medicine, Korea. kckeum@yumc.yonsei.ac.kr
2Department of Internal Medicine, Yonsei University College of Medicine, Korea.
3Department of Radiation Oncology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
The purpose of this study was to determine the potential role of three-dimensional conformal radiotherapy (3D-CRT) in the treatment of primary unresectable hepatocellular carcinoma. The preliminary results on the efficacy and the toxicity of 3D-CRT are reported.
Seventeen patients were enrolled in this study, which was conducted prospectively from January 1995 to June 1997. The exclusion criteria included the presence of extrahepatic metastasis, liver cirrhosis of Child-Pugh classification C, tumors occupying more than two thirds of the entire liver, and a performance status of more than 3 on the ECOG scale. Two patients were treated with radiotherapy only while the remaining 15 were treated with combined transcatheter arterial chemoembolization. Radiotherapy was given to the field including the tumor plus a 1.5 cm margin using a 3D-CRT technique. The radiation dose ranged from 36~60 Gy (median; 59.4 Gy). Tumor response was based on a radiological examination such as the CT scan, MR imaging, and hepatic artery angiography at 4~8 weeks following the completion of treatment. The acute and subacute toxicities were monitored.
An objective response was observed in 11 out of 17 patients, giving a response rate of 64.7%. The actuarial survival rate at 2 years was 21.2% from the start of radiotherapy (median survival; 19 months). Six patients developed a distant metastasis consisting of a lung metastasis in 5 patients and bone metastasis in one. The complications related to 3D-CRT were gastro-duodenitis (>or= grade 2) in 2 patients. There were no treatment related deaths and radiation induced hepatitis.
The preliminary results show that 3D-CRT is a reliable and effective treatment modality for primary unresectable hepatocellular carcinoma compared to other conventional modalities. Further studies to evaluate the definitive role of the 3D-CRT technique in the treatment of primary unresectable hepatocellular carcinoma are needed.
Key Words: Hepatocellular carcinoma, Radiotherapy, Conformal radiotherapy
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