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J Korean Soc Ther Radiol Oncol > Volume 19(4); 2001 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2001;19(4): 345-352.
Radiotherapy Results in Stage IIB Uterine Cervix Cancer
Whoon Jong Kil, Mison Chun, Seunghee Kang, Young Taek Oh, Hee Sug Ryu, Hee Jae Ju, Eun Ju Lee
ABSTRACT
PURPOSE:
To evaluate the treatment results and prognostic factors after radiotherapy in stage IIB uterine cervix cancer.
MATERIALS AND METHODS:
We retrospectively analyzed the records of 90 patients with stage IIB uterine cervix cancer who received radiotherapy between 9/94 and 12/99. Age was ranged from 28 to 79 years (median 57). Tumor size was > or = 4 cm in 64 patients. Preteatment SCC level was measured in 76 patients. Twenty nine patients received conventional radiotherapy (QD) and the others received modified hyperfractionated radiotherapy (BID). Only 7 patients in BID had tumor size <4 cm. All patients received high dose rate brachytherapy (4 Gy x 7 or 5 Gy x 6). No patient received concurrent chemotherapy during radiotherapy. Follow up period was ranging from 9 to 76 months (median 38).
RESULTS:
The 5-year overall and disease free survival rates were 73.4% and 71.6%, respectively. Local recurrences occurred in 10% of patients, and distant metastasis in 18.9%. There was a significant correlation between OS/DFS and tumor size (<4 cm; OS 95.2%, DFS 91.4%, > or = 4 cm; OS 63.4%, DFS 63.4%). Pretreatment SCC level was one of prognostic factors only in univariate analysis.
CONCLUSION:
With modified hyperfractionated radiotherapy, there was very low local recurrence rate (6.6%) and high 5-year overall and disease free survival rate (75.4% and 70.5%), which is comparable to results after concurrent chemoradiotherapy in bulky, locally advanced stage IIB uterine cervix cancer.
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