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J Korean Soc Ther Radiol Oncol > Volume 19(3); 2001 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2001;19(3): 224-229.
Analysis of Treatment Failure after Curative Radiotherapy in Uterine Cervical Carcinoma
Gyu Young Chai, Ki Mun Kang, Jong Hak Lee
1Department of Therapeutic Radiology, College of Medicine, Gyeongsang Institute of Cancer Research, Gyeongsang National University.
2Department of Obstetrics & Gynecology, College of Medicine, Gyeongsang Institute of Cancer Research, Gyeongsang National University.
The aim of this study is to analyze the treatment failure patterns and the risk factors for locoregional or distant failure of uterine cervical carcinoma treated with radiation therapy.
A retrospective analysis was undertaken of 154 patients treated with curative radiation therapy in Gyeongsang National University Hospital from April 1989 through December 1997. According to FIGO classification, 12 patients were stage IB, 24 were IIA, 98 were IIB, 1 were IIIA, 17 were IIIB, 2 were IVA.
Overall treatment failure rate was 42.1% (65/154), and that of complete responder was 31.5% (41/130). Among 65 failures, 25 failed locoregionally, another 25 failed distantly, and 15 failed locoregionally and distantly. Multivariate analysis confirmed tumor size (>4 cm) as risk factor for locoregional failure, and tumor size (>4 cm), pelvic lymph node involvement as risk factors for distant failure.
On the basis of results of our study and recent published data of prospective randomized study for locally advanced uterine cervical carcinoma, we concluded that uterine cervical carcinoma with size more than 4 cm or pelvic lymph node involvement should be treated with concurrent chemoradiation.
Key Words: Cervix cancer, Radiotherapy, Failure pattern
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