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J Korean Soc Ther Radiol Oncol > Volume 19(1); 2001 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2001;19(1): 10-15.
Results of Radiation Therapy in Nasopharyngeal Cancer
Moon June Cho, Ji Young Jang, Jun Sang Kim, Byung Kook Kim, Chang Joon Song, Jae Sung Kim
1Department of Therapeutic Radiology, College of Medicine, Cancer Research Institute, Chungnam National University, Taejon, Korea.
2Department of Otolaryngology, College of Medicine, Cancer Research Institute, Chungnam National University, Taejon, Korea.
3Department of Diagnostic Radiology, College of Medicine, Cancer Research Institute, Chungnam National University, Taejon, Korea.
ABSTRACT
PURPOSE:
This is a retrospective study to evaluate the results of radiation therapy in nasopharyngeal carcinoma.
MATERIALS AND METHODS:
From September 1989 to October 1996, 19 patients with nasopharyngeal carcinoma completed planned radiation therapy course. Stages were I in 2 patients, II in 6, III in 2 IV in 9 patients, respectively. Pathology was squamous cell carcinoma in 5 patients, undifferentiated cell carcinoma in 14 patients. Fourteen patients were treated with radiation therapy only. Five patients received chemotherapy. The follow-up period ranged from 5 months to 115 months with a median of 33 months. Follow-up was possible in all patients.
RESULTS:
Responses to radiation therapy were complete response in 15 patients, partial response in 2, and no response in 2, respectively. Patterns of failure were as follows : locoregional recurrence in 6 patients and distant metastasis in 4 patients. The sites of distant metastasis were bone, liver and lung. Five year survival rate was 47.8% and five year disease free survival rate was 48.1%. Stage, T-stage, N-stage, central nervous system involvement, pathology type, performance status, response, radiation dose, chemotherapy were not significant prognostic factors.
CONCLUSION:
5-year survival rate was 47.8% and 5-year disease free survival rate was 48.1%. The advances in radiation therapy techniques and chemotherapy are needed.
Key Words: Nasopharyngeal cancer, Radiation therapy
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