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J Korean Soc Ther Radiol Oncol > Volume 18(3); 2000 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2000;18(3): 187-193.
The Correlation between DNA Ploidy and the Clinicohistologic Findings in Colorectal Cancer
Suk Ho Lee, Hun Jung Kim, Woo Chul Kim, Young Kap Cho, Jun Kyu Loh, Ze Hong Woo, Tae Sook Hwang
1Department of Radiation Oncology, Inha University, College of Medicine, Inchon, Korea.
2Department of General Surgery, Inha University, College of Medicine, Inchon, Korea.
3Department of Anatomic pathology, Inha University, College of Medicine, Inchon, Korea.
ABSTRACT
PURPOSE:
DNA ploidy pattern was shown to correlate with several clinicohistologic findings in several tumors. Aim of this study was to evaluate the correlation of the clinicohistologic findings in colorectal cancer and the failure pattern in rectosigmoid cancer with DNA ploidy.
MATERIALS AND METHODS:
DNA flow cytometry using the Hedley methods on paraffin embedded specimen from 117 patients with colorectal cancers after curative resection was performed. We tried to find the correlation between DNA ploidy and various clinicohistologic findings. And then the correlation DNA ploidy and the failure pattern in 75 patients of rectosigmoid cancer was analized.
RESULTS:
Forty samples (34.2%) from tumors gave aneuploidy histogram. There was no significant difference in the frequency of DNA aneuploidy in terms of age, sex, depth of invasion, location and Dukes stage. But there was a significant correlation between DNA ploidy and the failure rates in Dukes stage B rectosigmoid cancer ( p=0.048).
CONCLUSIONS:
These findings suggest that DNA ploidy pattern shows the correlation with the treatment failure rates in Dukes stage B rectosigmoid, but not with many other clinicohistologic findings. However, more patients will be needed to disclose these findings.
Key Words: Colorectal cancer, DNA ploidy
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