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The Journal of the Korean Society for Therapeutic Radiology and Oncology 2000;18(2): 127-132. |
| The Change of Tumor Interstitial Fluid Pressure by Radiation Therapy in Patients with Metastatic Lymph Node in Head and Neck Area |
| Moon June Cho, Jae Sung Kim, Intae Lee, Jun Sang Kim, Ji Young Jang, Ki Hwan Kim |
1Department of Therapeutic Radiology, College of Medicine, Chungnam National University.
2Cancer Research Institute, Chungnam National University.
3Department of Radiation Oncology, School of Medicine, University of Pennsylvania. |
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| ABSTRACT |
PURPOSE:
To determine if the tumor intersitial fluid pressure (TIFP) and/or its change in patients with metastatic lymph node in head and neck area can predict radiotherapy outcome.
MATERIALS AND METHODS:
In 26 biopsy proven metastatic lymph node patients in head and neck area with accessible by direct inspection and palpation, and of sufficient thickness (>1 cm) to permit accurate needle placement, we measured TIFP at cervical lymph node before and during radiotherapy.
Tumor size was measured clinically and radiologically.
RESULTS:
The mean preradiotherapy TIFP was 24.7 mmHg.
Preradiotherapy TIFP had marginally significant relationship with tumor size ( p=0.06). Preradiotherapy TIFP significantly decreased when tumor size decreased ( p=0.009). Preradiotherapy TIFP was not different between complete response group and group with partial or less respone ( p=0.75). Radiotherapy outcome was not different between group with above and group with below than average TIFP ( p=0.229). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone.
CONCLUSION:
The mean TIFP was elevated with 24.7 mmHg.
Preradiotherapy TIFP had marginally significant relationship with tumor size ( p=0.06). TIFP decreased 36 mmHg in complete response group and 29.7 mmHg in group with partial or less respone but there was no statistically significant relationship in two groups. |
| Key Words:
Tumor intersitial fluid pressure, Radiotherapy, Head and neck cancer |
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