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J Korean Soc Ther Radiol Oncol > Volume 17(3); 1999 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 1999;17(3): 203-208.
Spontaneous Apoptosis and Metastasis in Squamous Cell Carcinoma of the Lung
Yoon Kyeong Oh, Keun Hong Kee
1Department of Therapeutic Radiology, Chosun University Medical College, Korea.
2Department of Pathology, Chosun University Medical College, Korea.
ABSTRACT
PURPOSE:
To evaluate whether spontaneous apoptosis has prognostic value among patients with squamous cell carcinoma of lung.
MATERIALS AND METHODS:
Material from 19 patients who received thoracic irradiation between 1990 and 1994 was analyzed. Their stages were II (1), IIIa (8), IIIb (5), and IV (5). Patients were observed from 5 to 67 months (median : 17 months). The spontaneous apoptosis index (AI) and p53 mutation were measured by immunohistochemical stains.
RESULTS:
AI was found to range from 0 to 1% (median 0.4%). Patients with low AI (AI< or =median) had a much higher distant metastasis rate at diagnosis than patients with high AI. By analysis of prognostic factors for survival, M stage was significant in univariate analysis. AI, chemotherapy, M stage, T stage, and stage were significant in multivariate analysis. The correlation between the AI and p53 mutation was not seen.
CONCLUSION:
AI was related with distant metastasis at diagnosis and not with p53 mutation. Also low AI group tended to have shorter survival time than high AI group.
Key Words: Lung cancer, Spontaneous apoptosis, Metastasis
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