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The Journal of the Korean Society for Therapeutic Radiology and Oncology 1999;17(3): 203-208. |
Spontaneous Apoptosis and Metastasis in Squamous Cell Carcinoma of the Lung |
Yoon Kyeong Oh, Keun Hong Kee |
1Department of Therapeutic Radiology, Chosun University Medical College, Korea. 2Department of Pathology, Chosun University Medical College, Korea. |
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ABSTRACT |
PURPOSE: To evaluate whether spontaneous apoptosis has prognostic value among patients with squamous cell carcinoma of lung.
MATERIALS AND METHODS: Material from 19 patients who received thoracic irradiation between 1990 and 1994 was analyzed. Their stages were II (1), IIIa (8), IIIb (5), and IV (5). Patients were observed from 5 to 67 months (median : 17 months). The spontaneous apoptosis index (AI) and p53 mutation were measured by immunohistochemical stains.
RESULTS: AI was found to range from 0 to 1% (median 0.4%).
Patients with low AI (AI< or =median) had a much higher distant metastasis rate at diagnosis than patients with high AI. By analysis of prognostic factors for survival, M stage was significant in univariate analysis. AI, chemotherapy, M stage, T stage, and stage were significant in multivariate analysis. The correlation between the AI and p53 mutation was not seen.
CONCLUSION: AI was related with distant metastasis at diagnosis and not with p53 mutation. Also low AI group tended to have shorter survival time than high AI group. |
Key Words:
Lung cancer, Spontaneous apoptosis, Metastasis |
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