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J Korean Soc Ther Radiol Oncol > Volume 17(1); 1999 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 1999;17(1): 1-8.
P53 Overexpression and Outcome of Radiation Therapy in Head & Neck Cancers
In Ah Kim, Ihl Bhong Choi, Ki Mun Kang, Ji Young Jang, Kyung Mi Kim, Kyung Shin Park, Young Shin Kim, Chang Suk Kang, Seung Ho Cho, Hyung Tae Kim
1Department of Radiation Oncology, St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
2Department of Clinical Pathology, St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
3Department of Otolaryngology, St. Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, Korea.
Experimental studies have implicated the wild type p53 in cellular response to radiation. Whether altered p53 function can lead to changes in clinical radiocurability remains an area of ongoing study. This study was performed to investigate whether any correlation between change of p53 and outcome of curative radiation therapy in patients with head and neck cancers.
Immunohistochemical analysis with a mouse monoclonal antibody (D0-7) specific for human p53 was used to detect to overexpression of protein in formalin fixed, paraffin-embedded tumor sample from 55 head and neck cancer patients treated with curative radiation therapy (median dose of 7020 cGy) from February 1988 to March 1996 at St. Mary's Hospital. Overexpression of p53 was correlated with locoregional control and survival using Kaplan-Meier method. A Cox regression multivariate analysis was performed that included all clinical variables and status of p53 expression.
Thirty-seven (67.2%) patients showed overexpression of p53 by immunohistochemical staining in their tumor. One hundred percent of oral cavity, 76% of laryngeal, 66.7% of oropharyngeal, 66.7% of hypopharyngeal cancer showed p53 overexpression (P=0.05). The status of p53 had significant relationship with stage of disease (P=0.03) and history of smoking (P=0.001). The overexpression of p53 was not predictive of response rate to radiation therapy. The locoregional control was not significantly affected by p53 status. Overexpression of p53 didn't have any prognostic implication for disease free survival and overall survival. Primary site and stage of disease were significant prognostic factors for survival.
The p53 overexpression as detected by immunohistochemical staining had significant correaltion with stage, primary site of disease and smoking habit of patients. The p53 overexpression didn't have any predictive value for outcome of curative radiation therapy in a group of head and neck cancers.
Key Words: p53, Radiation therapy, Head & neck cancer
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