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J Korean Soc Ther Radiol Oncol > Volume 16(4); 1998 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 1998;16(4): 399-408.
3-Dimensional Conformal Radiation Therapy in Carcinoma of The Nasopharynx
Ki Chang Keum, Gwi Eon Kim, Sang Hoon Lee, Sei Kyung Chang, John Jihoon Lim, Won Park, Chang Ok Suh
1Department of Radiation Oncology, Yonsei University, College of Medicine, Korea.
2Yonsei Cancer Center, Yonsei University, College of Medicine, Korea.
3Department of Radiation Oncology, Eulji Medical College, Seoul, Korea.
This study was designed to demonstrate the potential therapeutic advantage of 3-dimensional (3-D) treatment planning over the conventional 2-dimensional (2-D) approach in patients with carcinoma of the nasopharynx. MATERIAL AND
The two techniques were compared both qualitatively and quantitatively for the boost portion of the treatment (19.8 Gy of a total 70.2 Gy treatment schedule) in patient with T4. The comparisons between 2-D and 3-D plans were made using dose statistics, dose-volume histogram, tumor control probabilities, and normal tissue complication probabilities.
The 3-D treatment planning improved the dose homogeneity in the planning target volume. In addition, it caused the mean dose of the planning target volume to increase by 15.2% over 2-D planning. The mean dose to normal structures such as the temporal lobe, brain stem, parotid gland, and temporomandibular joint was reduced with the 3-D plan. The probability of tumor control was increased by 6% with 3-D treatment planning compared to the 2-D planning, while the probability of normal tissue complication was reduced.
This study demonstrated the potential advantage of increasing the tumor control by using 3-D planning, but prospective studies are required to define the true clinical benefit.
Key Words: Three-dimensional conformal radiation therapy, Nasopharyngeal carcinoma
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