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J Korean Soc Ther Radiol Oncol > Volume 16(2); 1998 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 1998;16(2): 115-123.
Chromosomal Aberration in Fractionated Radiotherapy
Hyong Geun Yun, Sung Whan Ha
1Department of Therapeutic Radiology, Dankook University College of Medicine, Chungnam, Korea.
2Department of Therapeutic Radiology, Seoul National University College of Medicine, Seoul, Korea.
ABSTRACT
PURPOSE:
This study was tried to evaluate the effect of the partial body fractionated irradiation on the frequency of chromosomal aberration.
MATERIALS AND METHODS:
In three patients with uterine cervix carcinoma, chromosomal aberrations were analyzed during fractionated external beam radiotherapy. Radiation field included whole pelvis and total dose was 5040 cGy in 28 fractions.
RESULTS:
The values of the frequency of dicentrics and rings (Ydr) in pre- irradiated peripheral lymphocytes in three patients were 0.0060, 0.0000, and 0.0029, respectively. The frequency of dicentrics and rings, estimated during the course of radiotherapy, increased with radiation dose and best fitted to the linear equation, Ydr=7.31x10(-5) D(cGy)+1.45x10(-2). The frequency of dicentrics and rings among the cells with dicentric and/or ring (Qdr) also showed increasing tendency and best fitted to the linear equation, Qdr= 1.01x10(-4) D(cGy)+1.04.
CONCLUSION:
Ydr increased linearly with radiation dose in the dose range of our study, and Qdr showed increasing tendency with dose.
Key Words: Biological dosimetry, Chromosomal aberration, Lymphocyte, Fractionated radiotherapy
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