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The Journal of the Korean Society for Therapeutic Radiology and Oncology 1998;16(1): 1-6. |
| Association of p53 Protein Expression with Clinical Outcome in Advanced Supraglottic Cancer |
| Jin Oh Kang, Seong Eon Hong |
| Department of Radiation Oncology, College of Medicine Kyung Hee University Hospital, Seoul, Korea. |
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| ABSTRACT |
PURPOSE:
To determine the incidence and prognostic effect of p53 expression in patients with advanced supraglottic cancer.
MATERIALS AND METHODS:
Twenty-one cases of total 48 advanced supraglottic cancer patients who received postoperative adjuvant radiation therapy were evaluated by immunohistochemical staining employing p53 monoclonal antibody.
RESULT:
Three out of six stage III patients and four out of fifteen stage IV patients showed p53 expression without statistically significant difference (P=0.608). Five year survival rates are 93% in p53 negative, 86% in p53 positive patients and there was no significant difference (P=0.776).
p53 expression does not show statistically significant correlation with primary tumor status (P=0.877), lymph node status (P=0.874) and age (P=0.64).
CONCLUSION:
There was no statistically significant correlation between traditionally known risk factors and p53 expression. |
| Key Words:
Supraglottic cancer, p53 expression, prognostic factor |
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