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J Korean Soc Ther Radiol > Volume 12(3); 1994 > Article
Journal of the Korean Society for Therapeutic Radiology 1994;12(3): 331-336.
Local Control after Radiation Therapy for T1-T2 Glottic Carcinoma
Byung Hyun Kwon, Dong Won Kim
Department of Radiation Therapy, Pusan National University Hospital, Dusan, Korea.
To assess the effectiveness and problems of the primary radiation therapy and salvage surgery in a series of patients affected by T1-T2 NO glottic cancers treated from 1985 to 1991 at the Pusan National University Hospital.
From 8.85 to 12/91, 34 patients affected by early glottic carcinoma histologically proven were treated with curative radiation therapy. Distribution of patients according to T stage was 30 for T1 and 4 T2. Male to female ratio was 33:1. Age of patients ranged from 31 to 73 with mean age of 58 years. All of the patients were treated with radical radiation with total tumor dose of 63-75. 3 Gy(median 68.2 Gy), of 5 weekly fractions of 1.8-2Gy and with 6MV photon beams through two laterally opposed fields.
The overall 5-year local control rates were 74%(8/30) for T1, and 25%(3/4) for T2. The main cause of failure was progression or recurrence in T(10/11). One failures were observed in T and N at the same time. Of these 11 patients, 9(81%) were salvaged with surgery. After surgical salvage of radiation failures, the 5-year survival rates were 96% for T1 and 75% T2. Among the survivors, 73% of T1 and 33% of T2 were able to preserve the larynx.
It can be concluded that radiotherapy is the first choice in the treatment of glottic T1 carcinoma.
Key Words: glottic carcinoma, radiation therapy, local control
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