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J Korean Soc Ther Radiol > Volume 12(2); 1994 > Article
Journal of the Korean Society for Therapeutic Radiology 1994;12(2): 143-150.
Pathologic Changes in the Rabbit lung Following Single Dose irradiation
Hyung Sik Lee, Young Min Choi, Won Joo Hur, Jin Sook Jeong, Young Hyun Yuh, Ki Nam Lee
1Department of Radiation Oncology, Dong-A University, College of Medicine, Korea.
2Department of Pathology, Dong-A University, College of Medicine, Korea.
3Department of Anatomy, Dong-A University, College of Medicine, Korea.
4Department of Diagnostic Radiology, Dong-A University, College of Medicine, Korea.
The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular, and organ levels. The cellular effects of irradiating the lungs are related to the histologic and clinical sequelae. In the present study the right lung of rabbits were exposed to single dose of 20 Gy of X-irradiation. Animals from each group were sacrificed monthly for 6 months postexposure. Sections of lung were examined by light microscopy(LM) and by transmission electron microscopy(TEM). Multiple exudative lesions were seen at 2 months after the 20Gy irradiation, and they progressed to a proliferative and then reparative fibrotic lesion by 6 months. Changes in epithelial lining of lung components, particulary the presence of type II pneumocytes were found by both LM and TEM. Capillary endothelial damages were less pronounced. The possible implication of cellular components in radiation pneumonitis and fibrosis is discussed.
Key Words: Radiation pneumonitis, fibrosis, rabbit
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