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J Korean Soc Ther Radiol > Volume 11(2); 1993 > Article
Journal of the Korean Society for Therapeutic Radiology 1993;11(2): 303-310.
Therapeutic Results of Radiation Therapy Alone and Combination with Chemotherapy in Non-Small Cell Lung Carcinoma
Ju Ree Kim, Hyun Suk Suh
Department of Radiation Oncology, Inje University, College of Medicine, Seoul Paik Hospital, Korea.
Between November 1983 and December 1992, 121 patients with non-small cell lung cancer were treated with radiotherapy alone or combined with chemotherapy in Inje University, Seoul Paik Hospital. Of these, 97 patients were evaluable and analyzed retrospectively. Group 1(n=62) was treated with radiotherapy alone and group 2(n=35) combined with chemotherapy. There were 7 patients, 1 patient with stage I and II, 20 patients, 11 patients with stage IIIA, 28 patients,20 patients with stage IIIB, and 6 patients, 3 patients with stage IV, respectively. Ninety percent of patients received more than 5000 cGy of radiaton. Median survival of patients in group 1 was 9 months, group 2 was 15 months. Overall 2 year survival rates of group 1 and 2 were 37% and 27%, respectively. Relapse free survival rates at 2 year were 27% and 15%, respectively. Overall survival rates at 5 year for group 1 and 2 were 15% and 11%, and relapse free survival rates were 16% and 6%, respectively. Median survival of complete and partial responders was 17 months in group 1, 18 Months in group 2, and those of stable or progression was 6 mouths, 11 months, respectively. The proportion of locoregional relapse and distant metastasis was not significantly different between group 1 and 2. The majority of relapse developed within 2 years. Although 2 cases of severe esophagitis and myelosuppression were noted in group 2, the treatment related toxicity was relatively acceptable. Our analysis showed no statistically significant differences between the two treatment groups in terms of response rate, survival, and sites of relapse.
Key Words: Non-small cell lung carcinoma, Radiotherapy alone, Combined modality with radiotherapy and chemotherapy
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