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J Korean Soc Ther Radiol > Volume 11(1); 1993 > Article
Journal of the Korean Society for Therapeutic Radiology 1993;11(1): 119-126.
Role of Radiotherapy in Unresectable Pancreatic Carcinoma
Hyun Soo Shin, Jinsil Seong, Won Yong Oh, Gwi Eon Kim
Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea
ABSTRACT
From 1988 to 1991, nineteen patients with unresectable localized pancreatic carcinoma were treated with radiotherapy and/or hyperthermia or in combination with chemotherapy. Radiation dose of 4500-5000 cGy with or without additional 500-1000 cGy was administered over 5 to 6 weeks to the pancreatic tumor area using 10 MV linear accelerator. Five of 19 patients were given chemotherapy, either neoadjuvant or maintenance setting with FAM regimen (5-FU, adriamycin and mitomycin C), which was repeated every 4 weeks for one year or until progression. Symptomatic palliation was achieved in 17 among 19 patients (89%) and objective response(complete or partial response in CT finding) was achieved in 5 among 11 patients (45%). The median survival time was 9 months and one-year survival rate, 32%. Local-regional failure was documented in 10 among 13 patients(77%) and distant failures were found in the liver (3 patients) and carcinomatosis (2 patients). Prognostic significance of various factors such as age, sex, performance status, tumor location, stage, etc. were assessed. Any factors did net have the prognostic significance in univariate analysis. Treatment was well tolerated in most of the patients with only wild to moderate toxicity.
Key Words: Pancreatic carcinoma, Unresectable, Radiotherapy
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