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J Korean Soc Ther Radiol > Volume 10(2); 1992 > Article
Journal of the Korean Society for Therapeutic Radiology 1992;10(2): 255-260.
Emergency Cranial Irradiation Effects in Adult Leukemia with Extremely High Leukocytosis
Seoung Ho Park, Moon June Cho, Samyong Kim
1Department of Radiology, College of Medicine Cancer Research Institute, Chungnam National University, Daeieon, Korea.
2Department of Infernal Medicine, College of Medicine Cancer Research Institute, Chungnam National University, Daeieon, Korea.
ABSTRACT
We have treated adult acute leukemia 64 patients between January 1990 and October 1991 at the Chungnam National University Hospital. They were examined for the impact of presenting WBC count on the initial course and from them we have chosen twenty patients whose leukocyte count is over one hundred thousands per cubic milimeter. We divided the twenty patients into 4 groups on the base of treatment modalities: conservative therapy only, chemotherapy only, cranial irradiation only, and chemotherapy with cranial irradiation. Early sudden death rate is lower in cranial irradiation with/without chemotherapy groups than the conservative only or chemotherapy only patients. Also the remission rate is high in cranial irradiation with chemotherapy patients. Therefore we suggest that the rapid intervention of cranial irradiation in adult acute leukemia could be helpful in reducing the early sudden death rate and perhaps in increasing the remission rate.
Key Words: Emergency cranial irradiation, Adult leukemia, Extremely high leukocytosis
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