| The Result of Radication Therapy for Adenocarcinoma of the Uterine Cervix |
| Ho Jun Lee, Jin Hee Kim, Ok Bae Kim |
| Department of Therapeutic Radiology,School of Medicine, Keimyung University, Taegu, korea. |
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| ABSTRACT |
PURPOSE:
This study was done to analyze prognostic factors and patterns failure of patients with histologically confirmed adenocarcinama of the uterine cervix.
MATERIALS AND METHODS:
From June 1988 to December 1996, a retrospective analysis was under taken for 45 patients who were treated with curative radiation therapy for adenocarcinoma of the to FIGO staging classification, 12 patients were stage lb, 9 patients were lla, 19 patients were llB, and 5 patients were lllb. Median age of the patients was 54 years. The radiation therapy consistes of a combination of external and intracavitary irradiation. Only the pelvis was treated for external irradiation of extended field irradiation including paraaortic nodes.Intracaviary irradiation was performed with high does rate sources (C0-60). Neoadjuvant chemotherapywas undertaken for 16 patients.Median and maximum follow-up duration was 54 and 113 months, respectively.
RESULT:
The overall 5-year survival rate was 55.2%, and the 5-year survival rates for stage lb, lla,,llb, and lllb were 100%,50.8%,46.8% and 49& (3-year survival rate),respectively. Of the many clinicopathologic variables evables evaluated for prognosis, only the stage and the tumor size were significant prognostic factors.
Statistically, pelvic falilure rates for stage lb, lla, llb, and lllb, were 0%, 33.3%,57.9%. and 60%, respectively.
Distant metastasis rates were 0%,33.3%,21.1%,and 40% for stage lb, lla, llb, and lllb, respectively. Especially the 6 patients who were irradiated with extended field to treat the paraaortic nodes were free of distant metastasis all.
But, 9 patients (23.1%) of the 39 patients who were not irradiated the paraaortic nodes were suffered and expired from uncontrolled distant metastasis.
CONCLUSION:
As compared with other studies, the survival rates were similar, but distant metastasis patients with stage II.So, we think that the effect of prophylactic paraaoric nodes irradiation should be studied prospectively, especially for patients with pelvic nodes involvenent or advanced stage of disease. |
| Key Words:
Cervical adenocarcinoma, Radiation therapy alone |
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