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J Korean Soc Ther Radiol > Volume 2(2); 1984 > Article
Journal of the Korean Society for Therapeutic Radiology 1984;2(2): 203-212.
Treatment of Unresectable Non-Small-Cell Lung Cancer with Curative Radiotherapy
Il han Kim, Sung Whan Ha, Charn Il Park, Young Soo Shim, Noe Kyeong Kim, Keun Youl Kim, Yong Chol Han
1Department of Radiology, College of Medicine, Seoul National University, Korea.
2Department of internal medicine, College of Medicine, Seoul National University, Korea.
From 1979 to 1982, 80 patients with unresectable non-mall-ell lung cancer without metastasis were treated with high-ose radiotherapy to the primary and to regional lymph nodes with or without supraclavicular lymphatic in the Department of Therapeutic radiology, Seoul National University Hospital. Of these, 56 patients (70%) were completely evaluable, and 59 patients (74%) had squamous cell carcinoma, 13% large cell undifferentiated carcinoma and 8% Aden carcinoma. 21 patients (26%) had Stage II and 59 patients (74%) had Stage III. The complete and partial response rate in the high-ose (~ 6,000rad) radiotherapy was 70% with 19% complete response. 69 patients (86%) failed in the treatment, by the failure pattern, 64% had local failure alone, 35% had local failure and distant metastasis and 1% had distant metastasis alone. The failure rate in the thorax was 76% in squamous cell carcinoma, 40% in Aden carcinoma and 20% in large cell undifferentiated carcinoma. Preliminary result shows that actuarial survival at 1, 2 and 3 years were 56%, 26% and 20% in overall patients and 64%, 37% and 21% in Stage II and 54%, 21% and 18% in Stage III, respectively. Overall median survival was 14 months; 17 months in Stage II and 13 months in Stage III. 8 patients (10%) have lived a minimum of 2 years with no evidence of disease. There was no fatal complication confirmed to be induced by radiotherapy, so definitive high-ose radiotherapy was tolerated well without major problems and resulted in good local control and survival.
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