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J Korean Soc Ther Radiol Oncol > Volume 23(1); 2005 > Article
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2005;23(1): 9-16.
Prediction of Prognosis to Concurrent Chemo-Radiotherapy by Standardized Uptake Value of 2-[18F] Fluoro-2-Deoxy-D-Glucose for Nasopharyngeal Carcinomas
Sang Wook Lee, Ki Chun Im, Soon Yuhl Nam, Jae Seung Kim, Eun Kyung Choi, Seung Do Ahn, Seong Soo Shin, Jin Sook Ryu, Sang Yoon Kim, Bong Jae Lee, Seung Ho Choi, Sung Bae Kim, Dae Hyuk Moon, Jong Hoon Kim
1Departments of Radiation Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. lsw@amc.seoul.kr
2Departments of Neclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
3Departments of Otorhinolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
4Departments of Medical Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
ABSTRACT
PURPOSE:
To prospectively evaluate the use of positron emission tomography with the glucose analog fluorodeoxyglucose (FDG-PET) to predict disease-free survival (DFS) after concurrent chemo-radiotherapy (CCRT) in patients with non-disseminated nasopharyngeal carcinoma (NPC). MATERIASL AND
METHODS:
We studied 41 patients with non-disseminated NPC scheduled to undergo platinum- based CCRT were eligible for this study. Patients were studied by FDG-PET prior to the CCRT. FDG uptake of tumors were measured with the maximal standardized uptake value (SUV).
RESULTS:
Complete response rate was 100%. In ten patients who presented with any component of treatment failure, the median SUVmax was 8.55 (range: 2.49~14.81) in any component of failure and the median SUVmax was 6.48 (range: 2.31~26.07) in the remaining patients without any such failure. Patients having tumors with high FDG uptake had a significantly lower 3-year DFS (51% v 91%, P=0.0070) compared with patients having low uptake tumors.
CONCLUSION:
FDG uptake, as measured by the SUV, has potential value in predicting DFS in NPC treated by CCRT. High FDG uptake may be a useful parameter for identifying patients requiring more aggressive treatment approaches.
Key Words: Nasopharyngeal carcinoma, FDG-PET, CCRT
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