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- Original Articles
- Feasibility and safety study of ultra-hypofractionated neoadjuvant radiotherapy to margins-at-risk in retroperitoneal sarcoma
- Ru-Xin Wong
 , Valerie Shi Wen Yang, Clarame Shulyn Chia, Wen Shen Looi, Wen Long Nei, Chin-Ann Johnny Ong
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Radiat Oncol J. 2025;43(1):6-12. Published online January 15, 2025
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Purpose: Retroperitoneal sarcomas (RPS) are rare tumors that present unique challenges, often due to late presentation, and the proximity of critical organs makes complete surgical resection challenging. This study aimed to assess the feasibility of neoadjuvant short-course radiotherapy (SCRT) targeting margins-at-risk and to assess its potential impact on outcomes.
Materials and Methods: This is a single-center, prospective, non-randomized feasibility study. SCRT... |
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- Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response
- Francesco Marampon
 , Giovanni Luca Gravina, Elisa Cinelli, Lucy Zaccaro, Miriam Tomaciello, Nunzia Di Meglio, Francesco Gentili, Alfonso Cerase, Armando Perrella, Mariya Yavorska, Sami Aburas, Luciano Mutti, Maria Antonietta Mazzei, Giuseppe Minniti, Paolo Tini
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Radiat Oncol J. 2025;43(1):13-21. Published online December 19, 2024
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Purpose: No guidelines exist to delineate radiation therapy (RT) targets for the treatment of multiple glioblastoma (mGBM). This study analyzes margins around the gross tumor volume (GTV) to create a clinical target volume (CTV), comparing response parameters and modalities of recurrence.
Material and Methods: One-hundred and three mGBM patients with a CTV margin of 2 cm (GTV + 2.0 cm) or... |
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- Promising application of nano-WO3/epoxy composite in intensity-modulated brachytherapy: a simulation study
- Erfan Saatchian
 , Shahrokh Naseri, Sare Hosseini, Hamid Gholamhosseinian
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Radiat Oncol J. 2025;43(1):22-29. Published online March 27, 2025
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Purpose: Implementing intensity-modulated brachytherapy (IMBT) techniques with high-energy sources like 60Co has always been challenging due to the clinical limitations of the applicator dimensions. This study aims to investigate using tungsten trioxide nanoparticles/epoxy composite as a shielding material to enhance the protective properties of a redesigned applicator.
Materials and Methods: The Geant4 application to tomographic emission, the Geant4-based Monte Carlo dose... |
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- Hounsfield units predict vertebral compression fractures in gastric cancer survivors after adjuvant irradiation
- Pervin Hurmuz
 , Yasin Ozyurek, Ecem Yigit, Suayib Yalcin, Fazli Yagiz Yedekci, Faruk Zorlu, Mustafa Cengiz
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Radiat Oncol J. 2025;43(1):30-39. Published online February 26, 2025
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Purpose: This study aimed to investigate the risk factors and predictive value of vertebral Hounsfield units (HUs) for vertebral compression fracture (VCF) development in gastric cancer (GC) patients who received adjuvant radiotherapy (RT).
Materials and Methods: We retrospectively analyzed the data of 271 patients with non-metastatic GC who received adjuvant RT between 2010 and 2020. The vertebral bodies from 9th thoracic... |
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- Planning evaluation of stereotactic magnetic resonance–guided online adaptive radiosurgery for kidney tumors close to the organ at risk: is it valuable to wait for good timing to perform stereotactic radiosurgery?
- Takaya Yamamoto
 , Shohei Tanaka, Noriyoshi Takahashi, Rei Umezawa, Yu Suzuki, Keita Kishida, So Omata, Kazuya Takeda, Hinako Harada, Kiyokazu Sato, Yoshiyuki Katsuta, Noriyuki Kadoya, Keiichi Jingu
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Radiat Oncol J. 2025;43(1):40-48. Published online March 17, 2025
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Purpose: This study aimed to investigate changes in target coverage using magnetic resonance–guided online adaptive radiotherapy (MRgoART) for kidney tumors and to evaluate the suitable timing of treatment.
Materials and Methods: Among patients treated with 3-fraction MRgoART for kidney cancer, 18 tumors located within 1 cm of the gastrointestinal tract were selected. Stereotactic radiosurgery planning with a prescription dose of 26... |
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- Case Report
- Long-term outcomes of radiotherapy for inoperable benign soft tissue tumors in the skull base or head
- Joo-Hyun Chung
 , Hak Jae Kim, Hyun-Cheol Kang, Il Han Kim, Joo Ho Lee
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Radiat Oncol J. 2025;43(1):49-54. Published online March 10, 2025
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This study aimed to evaluate the long-term efficacy and complication of radiotherapy for benign soft tissue tumors. Five cases of benign soft tissue tumors (two plexiform neurofibromas, two juvenile nasopharyngeal angiofibromas, and one cavernous sinus hemangioma) who underwent radiotherapy were enrolled. All patients had at least 10 years of follow-up. The median follow-up duration was 12 years (range, 10 to... |
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