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Table of Contents | March, 2016  Vol. 34  No.1 Previous Issue | Next Issue | Archive
In this issue:



Review Article
Brain metastasis in human epidermal growth factor receptor 2-positive breast cancer: from biology to treatment
Taeryool Koo, In Ah Kim
Radiat Oncol J. 2016;34(1):1-9.   Published online March 30, 2016

Overexpression of human epidermal growth factor receptor 2 (HER2) is found in about 20% of breast cancer patients. With treatment using trastuzumab, an anti-HER2 monoclonal antibody, systemic control is improved. Nonetheless, the incidence of brain metastasis does not be improved, rather seems to be increased in HER2-positive breast cancer. The mainstay treatment for brain metastases is radiotherapy. According to the...

Original Articles
Clinical Investigation
Patterns of failure after the reduced volume approach for elective nodal irradiation in nasopharyngeal carcinoma
Ki Ho Seol, Jeong Eun Lee
Radiat Oncol J. 2016;34(1):10-17.   Published online March 30, 2016
Purpose

To evaluate the patterns of nodal failure after radiotherapy (RT) with the reduced volume approach for elective neck nodal irradiation (ENI) in nasopharyngeal carcinoma (NPC).

Materials and Methods

Fifty-six NPC patients who underwent definitive chemoradiotherapy with the reduced volume approach for ENI were reviewed. The ENI included retropharyngeal and level II lymph nodes, and only encompassed the echelon inferior to the involved...

Volumetric modulated arc therapy for carotid sparing in the management of early glottic cancer
Young Suk Kim, Jaegi Lee, Jong In Park, Wonmo Sung, Sol Min Lee, Gwi Eon Kim
Radiat Oncol J. 2016;34(1):18-25.   Published online March 30, 2016
Purpose

Radiotherapy of the neck is known to cause carotid artery stenosis. We compared the carotid artery dose received between volumetric modulated arc therapy (VMAT) and conventional fixed-field intensity-modulated radiotherapy (IMRT) plans in patients with early glottic cancer.

Materials and Methods

Twenty-one early glottic cancer patients who previously underwent definitive radiotherapy were selected for this study. For each patient, double arc VMAT, 8-field...

Carotid sparing intensity modulated radiotherapy on early glottic cancer: preliminary study
Hoon Sik Choi, Bae Kwon Jeong, Hojin Jeong, Jin Ho Song, Jin Pyeong Kim, Jung Je Park, Seung Hoon Woo, Ki Mun Kang
Radiat Oncol J. 2016;34(1):26-33.   Published online March 30, 2016
Purpose

To compare the dose distribution between carotid sparing intensity modulated radiotherapy (IMRT) and opposed lateral field technique (LAFT), and to determine the effects of carotid sparing IMRT in early glottic cancer patients who have risk factors for atherosclerosis.

Materials and Methods

Ten early glottic cancer patients were treated with carotid sparing IMRT. For each patient, the conventional LAFT plan was developed for...

Prospective phase II trial of regional hyperthermia and whole liver irradiation for numerous chemorefractory liver metastases from colorectal cancer
Jeong Il Yu, Hee Chul Park, Doo Ho Choi, Jae Myoung Noh, Dongryul Oh, Jun Su Park, Ji Hyun Chang, Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Ho Yeong Lim, Won Ki Kang
Radiat Oncol J. 2016;34(1):34-44.   Published online March 30, 2016
Purpose

A prospective phase II trial was conducted to evaluate the effectiveness and toxicity of regional hyperthermia and whole liver irradiation (WLI) for numerous chemorefractory liver metastases from colorectal cancer.

Materials and Methods

Enrolled patients had numerous chemorefractory hepatic metastases from colorectal cancer. Five sessions of hyperthermia and seven fractions of 3-gray WLI were planned. Health-related quality of life (HRQoL) was determined using...

Hypofractionated intensity-modulated radiotherapy in patients with localized prostate cancer: a preliminary study
Hye Jin Kang, Chul-Seung Kay, Seok Hyun Son, Myungsoo Kim, In Young Jo, So Jung Lee, Dong Hwan Lee, Hong Jin Suh, Yong Sun Choi
Radiat Oncol J. 2016;34(1):45-51.   Published online March 30, 2016
Purpose

The aim of this work was to assess the efficacy and tolerability of hypofractionated intensity-modulated radiotherapy (IMRT) in patients with localized prostate cancer.

Materials and Methods

Thirty-nine patients who received radical hypofractionated IMRT were retrospectively reviewed. Based on a pelvic lymph node involvement risk of 15% as the cutoff value, we decided whether to deliver treatment prostate and seminal vesicle only radiotherapy...

FXYD-3 expression in relation to local recurrence of rectal cancer
Per Loftas, Gunnar Arbman, Xiao-Feng Sun, David Edler, Erik Syk, Olof Hallbook
Radiat Oncol J. 2016;34(1):52-58.   Published online March 30, 2016
Purpose

In a previous study, the transmembrane protein FXYD-3 was suggested as a biomarker for a lower survival rate and reduced radiosensitivity in rectal cancer patients receiving preoperative radiotherapy. The purpose of preoperative irradiation in rectal cancer is to reduce local recurrence. The aim of this study was to investigate the potential role of FXYD-3 as a biomarker for increased risk...

Local radiotherapy for palliation in multiple myeloma patients with symptomatic bone lesions
Jeong Won Lee, Jeong Eun Lee
Radiat Oncol J. 2016;34(1):59-63.   Published online March 30, 2016
Purpose

To evaluate the clinical outcomes of symptomatic bone lesions in patients with multiple myeloma (MM) who received local radiotherapy (LRT).

Materials and Methods

Fifty-one patients with 87 symptomatic bone lesions treated via LRT were analyzed. LRT was delivered at a median total dose of 21 Gy (range, 12 to 40 Gy) in a median of 7 fractions (range, 4 to 20 fractions)....

Physics Contribution
A feasibility study evaluating the relationship between dose and focal liver reaction in stereotactic ablative radiotherapy for liver cancer based on intensity change of Gd-EOB-DTPA-enhanced magnetic resonance images
Sang Hoon Jung, Jeong Il Yu, Hee Chul Park, Do Hoon Lim, Youngyih Han
Radiat Oncol J. 2016;34(1):64-75.   Published online March 30, 2016
Purpose

In order to evaluate the relationship between the dose to the liver parenchyma and focal liver reaction (FLR) after stereotactic ablative body radiotherapy (SABR), we suggest a novel method using a three-dimensional dose distribution and change in signal intensity of gadoxetate disodium-gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) hepatobiliary phase images.

Materials and Methods

In our method, change of...

Case Report
Radiotherapy in aggressive cutaneous pseudolymphoma: a case report and review of literature
Deepa Joseph, Monica Malik Irukulla, Syed Fayaz Ahmed, Deepthi Valiyaveettil, Syed Akram
Radiat Oncol J. 2016;34(1):76-80.   Published online March 30, 2016

Pseudolymphoma is a nonspecific disease characterized by lesions with lymphomatous-appearing but benign accumulation of inflammatory cells. They generally present as small ulcero-nodular lesions confined to skin which often respond to local therapies. We describe an unusual presentation of an extensive and locally aggressive cutaneous pseudolymphoma in a 21-year-old male patient who presented with extensive cutaneous eruptions gradually progressing over 6...

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